Bidkhori2012 Work-Precision Diagrams

The following benchmark is of 109 ODEs and 188 parameters that describe a stiff SBML model, modelling the EGFR signalling between normal and NSCLC cells Bidkhori et al.. It is referenced from Biomodels Database, and the model was parsed to Julia are finally to ODEs using ModelingToolkit.

using DiffEqBase, OrdinaryDiffEq, Catalyst, ReactionNetworkImporters,
      Sundials, Plots, DiffEqDevTools, ODEInterface, ODEInterfaceDiffEq,
      LSODA, TimerOutputs, LinearAlgebra, ModelingToolkit, BenchmarkTools, JLD2

gr()

par = load(joinpath(@__DIR__, "params_Bidkhori2012.jld2"))
Dict{String, Any} with 188 entries:
  "reaction_mw3994e898_7232_4b70_9c58_b3476e8655f5_mw3676a900_b098_4… => 10
.0
  "reaction_mw26fdabae_323b_4a78_b134_4c2eb70ea6a7_mw8b269d52_eda9_4… => 0.
2
  "reaction_mw584a64d0_560a_4297_9882_80cb4eff73f3_mwdf20ff60_f0b7_4… => 0.
05
  "reaction_mw5c806b00_59a1_491e_99a1_2c932b2d5d7a_mw5a798f7a_b4eb_4… => 20
.0
  "reaction_mw45d92b79_0656_4795_87d0_7a465949ca43_mwba545ecf_c7d4_4… => 1.
0
  "reaction_mwaa65a34e_fabf_4d6d_ae0b_f1d08b068f33_mw2eed2db0_ba78_4… => 0.
01833
  "reaction_mwc5aae1f8_52e4_4bcd_b044_3768f90b7b19_mwba77a9ba_078d_4… => 0.
2
  "reaction_mwd3a36af9_3ccc_4bb1_9867_3b9823ba4ac8_mw901b5284_bdae_4… => 0.
09
  "reaction_mw0a51fbf0_409b_4b45_b4ac_0220af4c4e3c_mw0b6eb5f7_b133_4… => 0.
01
  "reaction_mwb49058ff_2997_4187_abe7_4dce4ccf6ff4_mw432640ec_11b9_4… => 2.
9
  "reaction_mw0dd5a91d_d76c_494e_9dd6_57f2836aaa19_mw8ed5885f_774e_4… => 0.
001
  "reaction_mw9544e67b_b6d0_4941_b7e0_ecd4f400a335_mwb0744746_88a2_4… => 0.
2661
  "reaction_mwcf9f1b1d_e19a_4fa8_85ba_8f17e2cec730_mw1ddaf9f4_dcab_4… => 0.
0426
  "reaction_mwbb77e3d6_6065_4344_9361_e30c03514f4e_mw7e09242b_bd80_4… => 20
2.9
  "reaction_mw5c806b00_59a1_491e_99a1_2c932b2d5d7a_mw54178365_18c1_4… => 0.
1
  "reaction_mw602726ea_89ee_41b8_bda6_e2811bb42c1d_mw2e0b4751_7227_4… => 5.
0
  "reaction_mw85e457d1_73f8_4236_bb61_a128d300003f_mw97b9ab43_02ae_4… => 0.
005
  "reaction_mw7bb43f0a_c87e_41ff_8a43_cdf45c8f05e6_mwd12a67b3_6d98_4… => 2.
661
  "reaction_mwa67e40c1_693d_4214_adc8_b2f2b71cef12_mw575f7f49_3663_4… => 10
0.0
  ⋮                                                                   => ⋮

Defining the reaction system

function sbml_model!(du, u, p, t)
    # assignmentRule: variable = mwa6994523_5d45_4000_af0c_3e94073bf183
    u88 = u[80] + u[79]

    reaction_mwa67e40c1_693d_4214_adc8_b2f2b71cef12 = p["reaction_mwa67e40c1_693d_4214_adc8_b2f2b71cef12_mw575f7f49_3663_47f1_b492_5b92c1c4345d"] * u[1] * u[2] - p["reaction_mwa67e40c1_693d_4214_adc8_b2f2b71cef12_mw53c64fd3_9a1c_4947_a734_74a73554964c"] * u[3]

    reaction_mw877cd1e3_b48b_42e8_ab23_682dd893fd9d = p["reaction_mw877cd1e3_b48b_42e8_ab23_682dd893fd9d_mw8cfaf07f_dabe_45de_93cc_ef2c7fd31104"] * u[3] * u[3] - p["reaction_mw877cd1e3_b48b_42e8_ab23_682dd893fd9d_mwab52aceb_4b19_4317_b2da_97ccbb973dab"] * u[4]

    reaction_mw413c6d45_ab23_4d3e_87b3_a8ed4629b923 = p["reaction_mw413c6d45_ab23_4d3e_87b3_a8ed4629b923_mw6b97a1ec_2cba_4bce_96f7_ec1d0fa2d16c"] * u[4]

    reaction_mwf61e086d_0345_4d4c_b91d_0b105e543d04 = p["reaction_mwf61e086d_0345_4d4c_b91d_0b105e543d04_mwf1697f55_a3f4_4fb6_ae1d_f96f09ad1daa"] * u[5] * u[7] - p["reaction_mwf61e086d_0345_4d4c_b91d_0b105e543d04_mw880a5942_7549_4466_bd19_0e1768a3a533"] * u[8]

    reaction_mw91f49311_efdc_47c6_b8b8_a619e042d644 = p["reaction_mw91f49311_efdc_47c6_b8b8_a619e042d644_mw7e889122_d26c_4d09_bae4_d313b992dc8e"] * u[5] * u[9] - p["reaction_mw91f49311_efdc_47c6_b8b8_a619e042d644_mwff6f49f7_268a_4f08_8d36_3ad8449d7472"] * u[10]

    reaction_mw974c39f5_b82e_44b3_abec_7a724f46c526 = p["reaction_mw974c39f5_b82e_44b3_abec_7a724f46c526_mwe645e76e_bb00_4c22_b25e_a2e77a6aada2"] * u[8]

    reaction_mw9544e67b_b6d0_4941_b7e0_ecd4f400a335 = p["reaction_mw9544e67b_b6d0_4941_b7e0_ecd4f400a335_mwb0744746_88a2_488e_a483_266747a044c6"] * u[10]

    reaction_mw486c5261_3d03_4589_a1e9_978b62ad2dfe = p["reaction_mw486c5261_3d03_4589_a1e9_978b62ad2dfe_mw9e24066c_51a5_4c7a_af7c_4656155a4eb0"] * u[11] - p["reaction_mw486c5261_3d03_4589_a1e9_978b62ad2dfe_mwab1ef4d4_2acc_4fa2_b07c_fac51fb7bfaf"] * u[5] * u[12]

    reaction_mw2cf8a809_63d8_4717_91fc_070516e6f3db = p["reaction_mw2cf8a809_63d8_4717_91fc_070516e6f3db_mwc4824ff0_2b51_4d66_ad48_1145f670a6e1"] * u[12] * u[9] - p["reaction_mw2cf8a809_63d8_4717_91fc_070516e6f3db_mw0f1d282f_1c6b_455c_8254_3760632c6ecc"] * u[13]

    reaction_mweda6a945_fb5d_4d99_9958_11b2b2840308 = p["reaction_mweda6a945_fb5d_4d99_9958_11b2b2840308_mw0aa92e25_f9aa_461e_92b8_23b1b5b3ab92"] * u[13]

    reaction_mwd4bf58ea_70c9_43ea_a831_1fcde130ba28 = p["reaction_mwd4bf58ea_70c9_43ea_a831_1fcde130ba28_mw2a4ed8a2_fce4_44a4_adb9_edc24a06b4e1"] * u[12]

    reaction_mw4817365e_a33b_451f_bee1_de748377ede2 = p["reaction_mw4817365e_a33b_451f_bee1_de748377ede2_mwe879a9ac_4b8d_4c9a_a157_a3751761cf63"] * u[11] * u[14] - p["reaction_mw4817365e_a33b_451f_bee1_de748377ede2_mwa18578d7_236f_4939_baca_52259e38fe15"] * u[15]

    reaction_mw03998474_934b_4e4a_8c0c_ca359e402ac2 = p["reaction_mw03998474_934b_4e4a_8c0c_ca359e402ac2_mw289fed85_e6ee_43e6_a69f_77b5f487a452"] * u[15] * u[9] - p["reaction_mw03998474_934b_4e4a_8c0c_ca359e402ac2_mw8768b5c7_b227_4825_aa55_a525b0d915c2"] * u[16]

    reaction_mw7bb43f0a_c87e_41ff_8a43_cdf45c8f05e6 = p["reaction_mw7bb43f0a_c87e_41ff_8a43_cdf45c8f05e6_mwd12a67b3_6d98_40e9_a54b_282a577498eb"] * u[16]

    reaction_mwd9262331_e35a_4614_943a_89bcf8a492e3 = p["reaction_mwd9262331_e35a_4614_943a_89bcf8a492e3_mw6ac313e2_e8a9_42a9_b13a_27e55c1012a2"] * u[15] * u[17] - p["reaction_mwd9262331_e35a_4614_943a_89bcf8a492e3_mw93f832d7_eefb_43dd_853c_a0d7a76023cf"] * u[18]

    reaction_mwc5f121dc_d27d_4c3d_90f2_67d0adaf144a = p["reaction_mwc5f121dc_d27d_4c3d_90f2_67d0adaf144a_mwbb727dc5_30e8_45f4_9d15_3b34be5c1e93"] * u[14] * u[17] - p["reaction_mwc5f121dc_d27d_4c3d_90f2_67d0adaf144a_mw7ae1ee96_563e_4684_bc9a_8f4ef373620e"] * u[20]

    reaction_mw23a29b42_9813_4e46_b8ae_966e3215e6dc = p["reaction_mw23a29b42_9813_4e46_b8ae_966e3215e6dc_mwbc5340b6_06b7_4081_bd0c_e7a397f06a92"] * u[11] * u[20] - p["reaction_mw23a29b42_9813_4e46_b8ae_966e3215e6dc_mw0df80c0e_c32b_4f90_99bd_e8f90e4c8109"] * u[18]

    reaction_mw0e459167_515b_4c4d_8b67_bf0a5b3e9d61 = p["reaction_mw0e459167_515b_4c4d_8b67_bf0a5b3e9d61_mwc585e0e4_b7e7_4290_8a6d_10fcd9759a2d"] * u[5] * u[14] - p["reaction_mw0e459167_515b_4c4d_8b67_bf0a5b3e9d61_mwf44d37d0_fe7f_4e47_bf10_1e734fbc3391"] * u[21]

    reaction_mwc52e0f9b_1e0c_46ca_8d18_f05ef4a080cb = p["reaction_mwc52e0f9b_1e0c_46ca_8d18_f05ef4a080cb_mw3d564c3c_aa54_4c16_90be_662cfcbf8bc8"] * u[21] * u[9] - p["reaction_mwc52e0f9b_1e0c_46ca_8d18_f05ef4a080cb_mw371642bb_3836_4ded_93a5_68fa9b464896"] * u[22]

    reaction_mw4f89bf6c_8691_41a6_a1ac_13e6aa8c4b93 = p["reaction_mw4f89bf6c_8691_41a6_a1ac_13e6aa8c4b93_mw736e4a7b_4a25_4d32_b96b_b088e3bd41e7"] * u[22]

    reaction_mw35f71989_f89b_4440_b1a4_ebc7b4cc18b2 = p["reaction_mw35f71989_f89b_4440_b1a4_ebc7b4cc18b2_mw084cd67b_f328_48a7_8e16_1d6256c8c137"] * u[21] * u[17] - p["reaction_mw35f71989_f89b_4440_b1a4_ebc7b4cc18b2_mw43f177dc_f522_4dd1_b8e5_21b2b8fdfdba"] * u[23]

    reaction_mwd0d92dd4_81b7_4385_bfd7_5de82e193ecd = p["reaction_mwd0d92dd4_81b7_4385_bfd7_5de82e193ecd_mwfa6a58ab_0ca5_4c05_92b0_870593ac135d"] * u[5] * u[20] - p["reaction_mwd0d92dd4_81b7_4385_bfd7_5de82e193ecd_mwb9547c37_09b7_4258_95ab_8039d4088298"] * u[23]

    reaction_mwbb77e3d6_6065_4344_9361_e30c03514f4e = p["reaction_mwbb77e3d6_6065_4344_9361_e30c03514f4e_mw7e09242b_bd80_4af0_90c8_e0cddace89fe"] * u[18] * u[25] - p["reaction_mwbb77e3d6_6065_4344_9361_e30c03514f4e_mw2dfc8a19_1792_4e12_af38_8bfbda31a577"] * u[26]

    reaction_mw921ee820_1dbb_4b5f_866c_87da620d8f89 = p["reaction_mw921ee820_1dbb_4b5f_866c_87da620d8f89_mw553c0b3c_af7f_4309_8c61_0f1e2c32347c"] * u[27]

    reaction_mw0bcfad86_59b9_42ff_bcb7_fbb44845049d = p["reaction_mw0bcfad86_59b9_42ff_bcb7_fbb44845049d_mwfc146e94_8070_4727_8416_fb55829068cb"] * u[26]

    reaction_mwe9b50ac7_dac3_4eba_b1db_b3fd392d8fb7 = p["reaction_mwe9b50ac7_dac3_4eba_b1db_b3fd392d8fb7_mw26688d02_8ab9_4123_89c4_022b981cb72c"] * u[28]

    reaction_mw934c3638_603e_4ff0_a763_68f9405fa01f = p["reaction_mw934c3638_603e_4ff0_a763_68f9405fa01f_mw5639395a_a5cd_46dd_81b8_30fe72400a2e"] * u[23] * u[25] - p["reaction_mw934c3638_603e_4ff0_a763_68f9405fa01f_mw9cc637fe_d9ca_47d2_a4dc_66009d458094"] * u[28]

    reaction_mw3c617363_649b_4460_a694_36f7a3127a62 = p["reaction_mw3c617363_649b_4460_a694_36f7a3127a62_mw19173345_925d_427b_8658_add0978e5931"] * u[27] * u[29] - p["reaction_mw3c617363_649b_4460_a694_36f7a3127a62_mw9f6790d7_19ce_41d9_b4de_a1658c047501"] * u[30]

    reaction_mwf31259aa_32b7_4104_be70_045297b9a512 = p["reaction_mwf31259aa_32b7_4104_be70_045297b9a512_mw23e16d40_acbb_4658_a336_be5d0b0dd86a"] * u[30]

    reaction_mw0a51fbf0_409b_4b45_b4ac_0220af4c4e3c = p["reaction_mw0a51fbf0_409b_4b45_b4ac_0220af4c4e3c_mw10c97b8e_72aa_4f56_b3b9_c94baad7e213"] * u[5] * u[29] - p["reaction_mw0a51fbf0_409b_4b45_b4ac_0220af4c4e3c_mw0b6eb5f7_b133_4b3d_bf15_9fd6c2e9332d"] * u[31]

    reaction_mw33baddbd_a23f_45bb_b126_0ba60bbf6c53 = p["reaction_mw33baddbd_a23f_45bb_b126_0ba60bbf6c53_mwe483687f_b591_4c42_9abc_7ea9f47470bf"] * u[31] * u[27] - p["reaction_mw33baddbd_a23f_45bb_b126_0ba60bbf6c53_mwcf964aba_9db6_46c5_b687_beafc5d89169"] * u[32]

    reaction_mw652570eb_c9d3_499b_b877_61d360b10980 = p["reaction_mw652570eb_c9d3_499b_b877_61d360b10980_mwb881f20a_cf8a_493a_aa84_59ee90f26dd9"] * u[32]

    reaction_mwc5aae1f8_52e4_4bcd_b044_3768f90b7b19 = p["reaction_mwc5aae1f8_52e4_4bcd_b044_3768f90b7b19_mwb4c6ed27_c7ec_438f_bafd_4a09a9f356f1"] * u[31] * u[9] - p["reaction_mwc5aae1f8_52e4_4bcd_b044_3768f90b7b19_mwba77a9ba_078d_4ec6_a8b8_d7042a2cefe7"] * u[33]

    reaction_mw642ac312_2ee7_4e66_8f3e_e2da2bb6412a = p["reaction_mw642ac312_2ee7_4e66_8f3e_e2da2bb6412a_mwe1743f7b_ca2c_47d4_91d7_aed2748d98c5"] * u[33]

    reaction_mw584a64d0_560a_4297_9882_80cb4eff73f3 = p["reaction_mw584a64d0_560a_4297_9882_80cb4eff73f3_mw9f1dbbe6_8aa3_4180_bcea_04343649d7ba"] * u[34] * u[27] - p["reaction_mw584a64d0_560a_4297_9882_80cb4eff73f3_mwdf20ff60_f0b7_4c2a_b393_586ec1337e67"] * u[35]

    reaction_mw42c97708_4f85_45a8_9141_d0ae529409ca = p["reaction_mw42c97708_4f85_45a8_9141_d0ae529409ca_mw91f2ca92_9556_4fb8_ae12_0b72f3e3f261"] * u[35]

    reaction_mwaa65a34e_fabf_4d6d_ae0b_f1d08b068f33 = p["reaction_mwaa65a34e_fabf_4d6d_ae0b_f1d08b068f33_mw77c60377_28ae_4aad_b911_5768fc8b824f"] * u[36] * u[37] - p["reaction_mwaa65a34e_fabf_4d6d_ae0b_f1d08b068f33_mw2eed2db0_ba78_435b_b2c8_ee91efdba1b4"] * u[38]

    reaction_mw1bd186cf_4762_480a_b70d_d7a775462398 = p["reaction_mw1bd186cf_4762_480a_b70d_d7a775462398_mw7e974605_8d9c_4250_8f69_072aab1f24f7"] * u[38]

    reaction_mwf5573ddf_ad7f_478a_a784_557a9cddaaf2 = p["reaction_mwf5573ddf_ad7f_478a_a784_557a9cddaaf2_mw11cdaca9_941c_4a59_ba2a_3bfeafb65aeb"] * u[36] * u[39] - p["reaction_mwf5573ddf_ad7f_478a_a784_557a9cddaaf2_mw58c37b3e_91e7_445e_846e_77cd0b2320af"] * u[40]

    reaction_mwb49058ff_2997_4187_abe7_4dce4ccf6ff4 = p["reaction_mwb49058ff_2997_4187_abe7_4dce4ccf6ff4_mw432640ec_11b9_484d_ba26_415538ab9a10"] * u[40]

    reaction_mw8301b154_9463_4516_b4c5_c8f8b68691fe = p["reaction_mw8301b154_9463_4516_b4c5_c8f8b68691fe_mw11bb74b8_d908_46f0_ac4d_06e8dd1aa5ae"] * u[41] * u[42] - p["reaction_mw8301b154_9463_4516_b4c5_c8f8b68691fe_mwb44117f5_20b2_495e_adf3_3467cd119fd6"] * u[43]

    reaction_mwf95f743d_6108_49fe_8ffd_bdcc1a9f9a8d = p["reaction_mwf95f743d_6108_49fe_8ffd_bdcc1a9f9a8d_mwa4c71b8d_fb74_465b_b76e_cec4e4c95484"] * u[43]

    reaction_mw51d9d6b8_f0c0_4763_9d11_9be61b5cf5c9 = p["reaction_mw51d9d6b8_f0c0_4763_9d11_9be61b5cf5c9_mwc40b3165_cc16_4f78_86b5_e34f2731dcbb"] * u[41] * u[44] - p["reaction_mw51d9d6b8_f0c0_4763_9d11_9be61b5cf5c9_mw8bff2fe0_b582_4020_8f05_83f14451b1c0"] * u[45]

    reaction_mw6fd24d16_f57d_46c6_82f5_3f00759fa16b = p["reaction_mw6fd24d16_f57d_46c6_82f5_3f00759fa16b_mw3d07dc22_f821_49a5_9712_820ba9592353"] * u[45]

    reaction_mw9c208e18_c70d_4231_af0b_ad17cd0bba2d = p["reaction_mw9c208e18_c70d_4231_af0b_ad17cd0bba2d_mwa8f70790_9f44_4548_988e_49d13016d2f1"] * u[36] * u[47] - p["reaction_mw9c208e18_c70d_4231_af0b_ad17cd0bba2d_mwaad540b6_783e_4576_8862_ad522fd897db"] * u[48]

    reaction_mw87711dc1_43d7_40fc_b9e9_a24e2f92419d = p["reaction_mw87711dc1_43d7_40fc_b9e9_a24e2f92419d_mwfbc395b5_05b8_4e27_9696_c3ba52edaf74"] * u[48]

    reaction_mw4b445876_bdce_42d0_867b_fd3c74128a6b = p["reaction_mw4b445876_bdce_42d0_867b_fd3c74128a6b_mwc489f472_68ce_44e7_aad1_f8d2f6dda4ff"] * u[41] * u[49] - p["reaction_mw4b445876_bdce_42d0_867b_fd3c74128a6b_mw56f1bdc0_66fd_47c0_806a_beeaf123e2f2"] * u[50]

    reaction_mw40950d59_1012_4361_8418_73e25758e367 = p["reaction_mw40950d59_1012_4361_8418_73e25758e367_mwa17c895f_29d8_4977_a99f_cf9bf6216785"] * u[50]

    reaction_mwbfa79c95_487d_4c6f_b437_9e579451a419 = p["reaction_mwbfa79c95_487d_4c6f_b437_9e579451a419_mwafd23622_952d_44b3_a437_4aa12422add7"] * u[39] * u[49] - p["reaction_mwbfa79c95_487d_4c6f_b437_9e579451a419_mw9d9a7d08_b19a_44f1_a806_151597049345"] * u[51]

    reaction_mwa4b69c77_6226_46da_b78c_3e6027d0be41 = p["reaction_mwa4b69c77_6226_46da_b78c_3e6027d0be41_mwac85fd83_4e73_43f1_9c42_01773349d50f"] * u[51]

    reaction_mwf8bb22e2_5aa3_4c25_a022_a266b1856a48 = p["reaction_mwf8bb22e2_5aa3_4c25_a022_a266b1856a48_mwd23d026b_c5b7_4742_aab9_b9beb18ec9bc"] * u[46] * u[52] - p["reaction_mwf8bb22e2_5aa3_4c25_a022_a266b1856a48_mwf4c4d7a7_1498_4f6c_9d72_cd5cb012146c"] * u[54]

    reaction_mw61305f93_7b2d_4a2d_8d16_f7be026d8671 = p["reaction_mw61305f93_7b2d_4a2d_8d16_f7be026d8671_mwe3e5abe4_9f92_43eb_92e4_cea771f5bf14"] * u[54]

    reaction_mwcc31b497_6c50_446c_bbc2_6c5739507252 = p["reaction_mwcc31b497_6c50_446c_bbc2_6c5739507252_mwa617804d_95cc_4197_a39b_264a2c66b5a3"] * u[53]

    reaction_mw1d8c2435_bb85_4352_a25f_82033250579e = p["reaction_mw1d8c2435_bb85_4352_a25f_82033250579e_mw254868f8_c9fb_493c_bc1d_807cc83c18e6"] * u[44] * u[52] - p["reaction_mw1d8c2435_bb85_4352_a25f_82033250579e_mw78a41659_4abc_4614_9e83_38cbfe1c5262"] * u[53]

    reaction_mw8dec1159_1925_45d9_af25_3cb709a5017c = p["reaction_mw8dec1159_1925_45d9_af25_3cb709a5017c_mwbc2119ce_ade3_4e2a_a3bc_a29cd77adf72"] * u[46] * u[18] - p["reaction_mw8dec1159_1925_45d9_af25_3cb709a5017c_mw54b0e5e9_710f_438e_a8d3_749c594667bc"] * u[55]

    reaction_mwcf9f1b1d_e19a_4fa8_85ba_8f17e2cec730 = p["reaction_mwcf9f1b1d_e19a_4fa8_85ba_8f17e2cec730_mw1ddaf9f4_dcab_4dc2_a6fa_5ce85b9d7a3a"] * u[55]

    reaction_mwa5c135b4_77e2_4411_98e1_2000c39d4b30 = p["reaction_mwa5c135b4_77e2_4411_98e1_2000c39d4b30_mw60892818_7ef4_4f65_8003_9700a708c66c"] * u[46] * u[23] - p["reaction_mwa5c135b4_77e2_4411_98e1_2000c39d4b30_mw6843d346_6e9f_43d5_97f6_1059f164aa16"] * u[57]

    reaction_mw4685274a_2b55_429f_927f_3fd863592af6 = p["reaction_mw4685274a_2b55_429f_927f_3fd863592af6_mwdaa378da_64fe_4ea4_b79d_c25733837b9f"] * u[57]

    reaction_mw8e331e43_16b4_478d_880b_d5a3244540e4 = p["reaction_mw8e331e43_16b4_478d_880b_d5a3244540e4_mw3f5e2165_9bb6_4ac3_992e_50943dd2ea05"] * u[56]

    reaction_mw47dee769_daa0_4af4_978a_5ab17e504c2f = p["reaction_mw47dee769_daa0_4af4_978a_5ab17e504c2f_mwe49ede89_014e_40f2_acfd_0d1a0cd11fe7"] * u[58]

    reaction_mwbd8a133e_1b70_44e8_bef8_78b14141166b = p["reaction_mwbd8a133e_1b70_44e8_bef8_78b14141166b_mw90873203_7a5d_4fca_a789_5e989ff0c999"] * u[18] * u[6] - p["reaction_mwbd8a133e_1b70_44e8_bef8_78b14141166b_mw92d81b3b_fa59_4637_8540_8cb8482490d9"] * u[19]

    reaction_mw3a87ca5a_845d_4ac4_8806_e343cbbfc630 = p["reaction_mw3a87ca5a_845d_4ac4_8806_e343cbbfc630_mwcc2a950d_261b_4fd7_9c08_9f3c194ba09d"] * u[19] * u[60] - p["reaction_mw3a87ca5a_845d_4ac4_8806_e343cbbfc630_mw1351daea_68be_404a_b7b0_105920ff3371"] * u[59]

    reaction_mw363a5271_1f51_4d5e_87a7_42ea25cb5657 = p["reaction_mw363a5271_1f51_4d5e_87a7_42ea25cb5657_mwc6b3c76f_af7b_488c_8751_28f1d9ab90a1"] * u[59]

    reaction_mw6bee0112_92dc_4169_9109_2633772b3aa4 = p["reaction_mw6bee0112_92dc_4169_9109_2633772b3aa4_mwf9c81339_e73a_45b5_a714_0854b718d44f"] * u[23] * u[6] - p["reaction_mw6bee0112_92dc_4169_9109_2633772b3aa4_mw587125c7_6092_4627_9cdd_2415b77a8307"] * u[24]

    reaction_mwbac9e6ff_2df1_45eb_b3f4_4cae74c64014 = p["reaction_mwbac9e6ff_2df1_45eb_b3f4_4cae74c64014_mwa575cf96_3d57_4222_ac71_bd17006ef035"] * u[24] * u[60] - p["reaction_mwbac9e6ff_2df1_45eb_b3f4_4cae74c64014_mwf7658bc6_acb6_411e_ae2c_9d8de7738d5f"] * u[61]

    reaction_mweb93165f_cf03_48f1_b035_59d79e324314 = p["reaction_mweb93165f_cf03_48f1_b035_59d79e324314_mwa137184a_0eb0_4bcb_971c_8e19231b2c07"] * u[61]

    reaction_mw85e457d1_73f8_4236_bb61_a128d300003f = p["reaction_mw85e457d1_73f8_4236_bb61_a128d300003f_mwfa680314_051c_4b10_afc9_7e7fbee49e3f"] * u[5] * u[6] - p["reaction_mw85e457d1_73f8_4236_bb61_a128d300003f_mw97b9ab43_02ae_4e42_a524_6b781633a255"] * u[62]

    reaction_mw6b159c8f_eee0_4337_b711_2e230c9e2cf6 = p["reaction_mw6b159c8f_eee0_4337_b711_2e230c9e2cf6_mwcc0d3fcd_9b9e_4390_b588_e57b57d89d22"] * u[62] * u[60] - p["reaction_mw6b159c8f_eee0_4337_b711_2e230c9e2cf6_mw56f1be7e_e303_4a72_be17_5bd08e3eb1f2"] * u[63]

    reaction_mwc9b3b248_3290_452a_9b7c_8fdada3e6687 = p["reaction_mwc9b3b248_3290_452a_9b7c_8fdada3e6687_mw1decb177_5075_41f3_a348_ca13b8f4497e"] * u[63]

    reaction_mw77484632_4e33_468a_9937_24e9bfd0e17d = p["reaction_mw77484632_4e33_468a_9937_24e9bfd0e17d_mw001b8124_b461_482a_8c8e_30bffc6718f7"] * u[5] * u[64] - p["reaction_mw77484632_4e33_468a_9937_24e9bfd0e17d_mw40eca7d6_80b2_4926_9c2f_330422db0814"] * u[65]

    reaction_mw2c5858f3_0988_49b0_a94a_057853b84e91 = p["reaction_mw2c5858f3_0988_49b0_a94a_057853b84e91_mwf3d00ca5_89dc_4693_92ec_a47db8150144"] * u[65] - p["reaction_mw2c5858f3_0988_49b0_a94a_057853b84e91_mw91a84697_3231_4fa6_b6ff_d69ee86056dc"] * u[66]

    reaction_mwd3a36af9_3ccc_4bb1_9867_3b9823ba4ac8 = p["reaction_mwd3a36af9_3ccc_4bb1_9867_3b9823ba4ac8_mw901b5284_bdae_4040_b77d_10f1ec267f06"] * u[65] - p["reaction_mwd3a36af9_3ccc_4bb1_9867_3b9823ba4ac8_mw94cadd24_0432_4f89_a6fc_96cb0475c44e"] * u[5] * u[67]

    reaction_mw9f000f29_2512_4d4a_9dd9_e59aaf296d31 = p["reaction_mw9f000f29_2512_4d4a_9dd9_e59aaf296d31_mw688106ee_719d_4995_b1a0_faeefdb0af5a"] * u[68] * u[67] - p["reaction_mw9f000f29_2512_4d4a_9dd9_e59aaf296d31_mw85c8ff7d_8d7c_4403_8a58_4996a3e6ac28"] * u[69]

    reaction_mw837b5ad7_4a8c_4c55_94ff_0fdd63048044 = p["reaction_mw837b5ad7_4a8c_4c55_94ff_0fdd63048044_mw4f6f44d9_408e_49b2_bedf_d34b2448725e"] * u[69]

    reaction_mwd15926b3_069a_4b16_a6fc_c0c15083d621 = p["reaction_mwd15926b3_069a_4b16_a6fc_c0c15083d621_mwd3e2533f_8d57_407c_834d_e0dde30b7f4a"] * u[70] - p["reaction_mwd15926b3_069a_4b16_a6fc_c0c15083d621_mwbd416b7b_f9b6_4464_b9e8_be4ac001d13d"] * u[68] * u[64]

    reaction_mw3a5e0932_d50f_4fe6_b8cb_0ad649f305b0 = p["reaction_mw3a5e0932_d50f_4fe6_b8cb_0ad649f305b0_mw64664eb9_353a_4f1d_a8dc_e22bcb06e2c2"] * u[67] * u[71] - p["reaction_mw3a5e0932_d50f_4fe6_b8cb_0ad649f305b0_mw0573df9d_f365_40b7_83d4_3846a05aefdc"] * u[72]

    reaction_mw5dcc8719_3180_4bd0_8797_08e256131961 = p["reaction_mw5dcc8719_3180_4bd0_8797_08e256131961_mw134431c3_e8e5_4375_89a0_2c51a03d65dd"] * u[72]

    reaction_mw376b0685_ef73_4fcc_94af_2ada24cf8a8b = p["reaction_mw376b0685_ef73_4fcc_94af_2ada24cf8a8b_mw22510791_ef7e_4373_907c_9eecbc8adda7"] * u[74] * u[73] - p["reaction_mw376b0685_ef73_4fcc_94af_2ada24cf8a8b_mwf59d397b_cfee_4a84_9279_134cc951db8c"] * u[75]

    reaction_mwcc7cfa9c_4945_403a_938e_b237c371a5ef = p["reaction_mwcc7cfa9c_4945_403a_938e_b237c371a5ef_mwe2aded94_f2b5_4513_8670_71a86abf7968"] * u[75] * u[76] - p["reaction_mwcc7cfa9c_4945_403a_938e_b237c371a5ef_mw8d6eacb6_7184_4564_8cde_53e93add2146"] * u[77]

    reaction_mw98da32e0_b061_40c5_9d32_40744134f3fa = p["reaction_mw98da32e0_b061_40c5_9d32_40744134f3fa_mw3c3648cb_6d56_4d9d_be47_129483778fd6"] * u[77]

    reaction_mw31369230_1f14_45bd_be02_a44a275c6e31 = p["reaction_mw31369230_1f14_45bd_be02_a44a275c6e31_mw98405e53_330b_4a64_a700_a62bb3f21426"] * u[78] - p["reaction_mw31369230_1f14_45bd_be02_a44a275c6e31_mw11f8de84_6639_486d_bf17_8f7021f54b66"] * u[79] * u[76]

    reaction_mw12311a84_3f8d_40c6_8b14_961a8a58d1b6 = p["reaction_mw12311a84_3f8d_40c6_8b14_961a8a58d1b6_mw65e1222f_39ad_4a29_ae76_04b7d591af38"] * u[79] - p["reaction_mw12311a84_3f8d_40c6_8b14_961a8a58d1b6_mw11e520e6_b1f1_4802_af71_92a2bd9cb644"] * u[80] * u[73]

    reaction_mwf3d393e9_ae09_4eab_a39a_ed0eef0f54bc = p["reaction_mwf3d393e9_ae09_4eab_a39a_ed0eef0f54bc_mw6a4e035b_11a7_4155_9a78_cfba13631cb1"] * u[81]

    reaction_mw2698f402_d00b_451e_8b22_93a322fe9a92 = p["reaction_mw2698f402_d00b_451e_8b22_93a322fe9a92_mw6eebbe41_cf28_46e8_930c_26f50e08d602"] * u[82] - p["reaction_mw2698f402_d00b_451e_8b22_93a322fe9a92_mw751c2663_d807_482f_991b_c8032cb6d996"] * u[74] * u[83]

    reaction_mw028e8b3e_b531_4466_9c3a_e3fcf7fc9be9 = p["reaction_mw028e8b3e_b531_4466_9c3a_e3fcf7fc9be9_mwd2d0b340_bbdb_40bd_9eac_992a2a402b94"] * u[80] * u[83] - p["reaction_mw028e8b3e_b531_4466_9c3a_e3fcf7fc9be9_mwb1b46773_a218_4f99_a000_a98fbc1275d7"] * u[81]

    reaction_mwc5e0c166_6a3a_4913_9ed1_dafe97bdb371 = p["reaction_mwc5e0c166_6a3a_4913_9ed1_dafe97bdb371_mw193f2553_1ab3_4b07_9b4b_201ee9e08c96"] * u[79] * u[83] - p["reaction_mwc5e0c166_6a3a_4913_9ed1_dafe97bdb371_mwb7292ff5_dd13_41aa_b9b8_2c0c75d35fb1"] * u[84]

    reaction_mw94b3bae0_4da9_4358_a5ac_a46a5cbf621b = p["reaction_mw94b3bae0_4da9_4358_a5ac_a46a5cbf621b_mwf4069175_b898_4633_ac1e_20f44431c36a"] * u[84]

    reaction_mw362ca1b3_224a_42fb_a14b_6ff467748a5e = p["reaction_mw362ca1b3_224a_42fb_a14b_6ff467748a5e_mw6d852e8c_c64a_4926_80c4_781a9c04b20e"] * u[85] - p["reaction_mw362ca1b3_224a_42fb_a14b_6ff467748a5e_mw4d614bfc_3e20_450e_8890_6326afd0a0d7"] * u[75] * u[83]

    reaction_mw3994e898_7232_4b70_9c58_b3476e8655f5 = p["reaction_mw3994e898_7232_4b70_9c58_b3476e8655f5_mw3676a900_b098_4a74_a511_e15984ca0cd2"] * u[78] * u[83] - p["reaction_mw3994e898_7232_4b70_9c58_b3476e8655f5_mwf68a0726_94b5_4be1_933f_1ac48053601d"] * u[86]

    reaction_mw75acd2d1_3fdf_4c3f_8d99_6d62f825d5e2 = p["reaction_mw75acd2d1_3fdf_4c3f_8d99_6d62f825d5e2_mwb4f0353c_d140_44cc_ab75_566fcc2909c5"] * u[86]

    reaction_mw4a334f7d_9bce_4690_b623_a427ed66a174 = p["reaction_mw4a334f7d_9bce_4690_b623_a427ed66a174_mw6165953d_ce44_4b21_a18a_c401c04993f1"] * u[87] - p["reaction_mw4a334f7d_9bce_4690_b623_a427ed66a174_mw99a30aef_212a_4577_bcfd_8c5764057cca"] * u[77] * u[83]

    reaction_mw950485f2_4463_4309_a4e4_cc81d16ffb7f = p["reaction_mw950485f2_4463_4309_a4e4_cc81d16ffb7f_mw94b0216f_3353_4b36_b9b7_fd34a0510b08"] * u88 * u[36] / (p["reaction_mw950485f2_4463_4309_a4e4_cc81d16ffb7f_mw2034bbe7_27cc_410c_9870_1f8a5986dfa5"] + u[36])

    reaction_mw62f71309_e066_47d2_9b99_01f78a51c218 = p["reaction_mw62f71309_e066_47d2_9b99_01f78a51c218_mw0cea56f3_1cdb_410e_a5a4_f3635ba5c94b"] * u[89]

    reaction_mwe8647e48_f4a9_40f4_9b32_f89ded572e01 = p["reaction_mwe8647e48_f4a9_40f4_9b32_f89ded572e01_mw50a0e884_a88c_46a7_b985_788868bc1029"] * u[5] * u[90] - p["reaction_mwe8647e48_f4a9_40f4_9b32_f89ded572e01_mw2c88e0e2_e9c3_4e4c_bb2e_b0cd1f6420f4"] * u[91]

    reaction_mw65b9e026_bc6c_4c94_8b37_8b9acdf50c8a = p["reaction_mw65b9e026_bc6c_4c94_8b37_8b9acdf50c8a_mw95e2190d_8e39_419b_ad26_7cc141f7b87b"] * u[91]

    reaction_mw1c9d29fa_bff4_4d2f_9d5f_f1791e4882a3 = p["reaction_mw1c9d29fa_bff4_4d2f_9d5f_f1791e4882a3_mw76d68ace_272d_4178_bba2_74dfdf260c70"] * u[5] * u[92] - p["reaction_mw1c9d29fa_bff4_4d2f_9d5f_f1791e4882a3_mwe37b936f_7781_4a01_b59b_96bd7db0c49e"] * u[93]

    reaction_mwad97bd5a_3dae_49d9_990b_2e6574740618 = p["reaction_mwad97bd5a_3dae_49d9_990b_2e6574740618_mwb6701ead_d3f2_4eb3_8b08_341cea49a4b2"] * u[92] * u[94] - p["reaction_mwad97bd5a_3dae_49d9_990b_2e6574740618_mwa5016035_3f9f_44fc_9f69_1d7a0155eb36"] * u[95]

    reaction_mwe9988e4a_083c_4f8e_b154_3e599c9307b0 = p["reaction_mwe9988e4a_083c_4f8e_b154_3e599c9307b0_mw26164d03_adda_4a21_b5ac_59e1d5a8d8ab"] * u[95]

    reaction_mwf8bacf1a_6c1a_49b6_b344_2d3bd404a735 = p["reaction_mwf8bacf1a_6c1a_49b6_b344_2d3bd404a735_mw9fe16c2b_7271_4e4f_b6de_c149721a3198"] * u[92] * u[92] - p["reaction_mwf8bacf1a_6c1a_49b6_b344_2d3bd404a735_mw74ea5b55_ead0_4b6f_8da0_fd1dcf7e231d"] * u[97]

    reaction_mwc9b945cf_3a14_4bd9_b253_7064498c75e2 = p["reaction_mwc9b945cf_3a14_4bd9_b253_7064498c75e2_mw8cbe6595_6f16_4704_afe2_0dd043a175fa"] * u[97] * u[94] - p["reaction_mwc9b945cf_3a14_4bd9_b253_7064498c75e2_mw21d22acd_ddd4_4794_9700_52201984f75b"] * u[96]

    reaction_mw75c6078f_fb76_4ca9_9fdd_e221e3ba57ad = p["reaction_mw75c6078f_fb76_4ca9_9fdd_e221e3ba57ad_mw81384973_14a0_4498_ab21_f70666d46d7f"] * u[96]

    reaction_mw177fa7b0_f0be_4c3e_8b47_2ac4e13159a2 = p["reaction_mw177fa7b0_f0be_4c3e_8b47_2ac4e13159a2_mw9f1a7f64_0b37_42df_9dd5_e1a44efdcbba"] * u[90] * u[92] - p["reaction_mw177fa7b0_f0be_4c3e_8b47_2ac4e13159a2_mw366e6f17_4081_4cdc_9fa5_0aeb354d692c"] * u[98]

    reaction_mwec4127b5_6bcf_4128_aff4_a6b3c470f690 = p["reaction_mwec4127b5_6bcf_4128_aff4_a6b3c470f690_mw1df2caba_8e41_4fe5_a1b5_7777eb98ed1c"] * u[97]

    reaction_mw5c806b00_59a1_491e_99a1_2c932b2d5d7a = p["reaction_mw5c806b00_59a1_491e_99a1_2c932b2d5d7a_mw5a798f7a_b4eb_4a27_b413_4ff3956b90e9"] * u[100] * u[100] - p["reaction_mw5c806b00_59a1_491e_99a1_2c932b2d5d7a_mw54178365_18c1_47e0_94ee_6b96582c52ef"] * u[99]

    reaction_mw26fdabae_323b_4a78_b134_4c2eb70ea6a7 = p["reaction_mw26fdabae_323b_4a78_b134_4c2eb70ea6a7_mw1ff4e75e_fce5_4a7a_907b_05df4981f80b"] * u[99] * u[101] - p["reaction_mw26fdabae_323b_4a78_b134_4c2eb70ea6a7_mw8b269d52_eda9_4dd1_8616_ebcf29c971fa"] * u[102]

    reaction_mw3b0c171c_6d60_41ca_8193_83cd5e6c188c = p["reaction_mw3b0c171c_6d60_41ca_8193_83cd5e6c188c_mw90b25c4b_ad1a_4ee5_ae20_c60451484516"] * u[102]

    reaction_mwc38a99c8_74cf_49f2_a16b_f6610ca1a0a7 = p["reaction_mwc38a99c8_74cf_49f2_a16b_f6610ca1a0a7_mwa0806e7a_a90d_4187_9c37_6d9ea569a447"] * u[104] * u[100] - p["reaction_mwc38a99c8_74cf_49f2_a16b_f6610ca1a0a7_mw95cb9071_56e2_447d_b7c7_59ac96baa623"] * u[103]

    reaction_mw45d92b79_0656_4795_87d0_7a465949ca43 = p["reaction_mw45d92b79_0656_4795_87d0_7a465949ca43_mwba545ecf_c7d4_4a6c_8c47_9e91f052d5a9"] * u[100] * u[101] - p["reaction_mw45d92b79_0656_4795_87d0_7a465949ca43_mw01c5ceef_57a1_4baa_b2cd_fd39e9588a10"] * u[105]

    reaction_mwb71945c2_03a8_4fad_a995_e1caeee98525 = p["reaction_mwb71945c2_03a8_4fad_a995_e1caeee98525_mw7aba6db3_c7ec_4192_bb5e_0ac4b466c1a5"] * u[105]

    reaction_mwd189238c_e8f9_40be_b4ea_18a42bba1b4f = p["reaction_mwd189238c_e8f9_40be_b4ea_18a42bba1b4f_mw31eb851a_c381_419d_b694_f158b7f5cfb6"] * u[104]

    reaction_mwcb637bf1_7618_4d8a_ab5c_399145ecf1df = p["reaction_mwcb637bf1_7618_4d8a_ab5c_399145ecf1df_mwe09b67b9_0d2a_4b82_91ef_5284216beb94"] * u[91] * u[6] - p["reaction_mwcb637bf1_7618_4d8a_ab5c_399145ecf1df_mw77a6c207_ff8c_463c_9b4e_8a7d96652b79"] * u[106]

    reaction_mw401dde7e_c0a1_4780_b6cc_8f98681c862e = p["reaction_mw401dde7e_c0a1_4780_b6cc_8f98681c862e_mw1df53838_48e5_4331_9084_3790409ad5ff"] * u[106] * u[60] - p["reaction_mw401dde7e_c0a1_4780_b6cc_8f98681c862e_mwe4573b2c_5f99_40d0_9f9e_c238caa5ccbe"] * u[107]

    reaction_mw0dd5a91d_d76c_494e_9dd6_57f2836aaa19 = p["reaction_mw0dd5a91d_d76c_494e_9dd6_57f2836aaa19_mw8ed5885f_774e_48a0_9338_fe8cdd512023"] * u[107]

    reaction_mwb205f533_4013_406b_8a4b_691ec3949555 = p["reaction_mwb205f533_4013_406b_8a4b_691ec3949555_mwa6ef5f75_f152_414d_811c_dd037d4b3ca1"] * u[65] * u[6] - p["reaction_mwb205f533_4013_406b_8a4b_691ec3949555_mwee51df1b_3f69_43f8_a1d5_5a8c5d0215f2"] * u[108]

    reaction_mw602726ea_89ee_41b8_bda6_e2811bb42c1d = p["reaction_mw602726ea_89ee_41b8_bda6_e2811bb42c1d_mw2e0b4751_7227_4815_bf6f_fa5e2370b1d3"] * u[108] * u[60] - p["reaction_mw602726ea_89ee_41b8_bda6_e2811bb42c1d_mwa8eec8e9_74b9_4afc_b6db_1116fe48e858"] * u[109]

    reaction_mwfab3a9ec_b094_44f0_bd59_12ac56ca1c99 = p["reaction_mwfab3a9ec_b094_44f0_bd59_12ac56ca1c99_mwc3426c7e_3452_4507_9189_4b83ab147bdd"] * u[109]

    reaction_mw4fceada8_6eb0_4230_a083_b2ab094d2961 = p["reaction_mw4fceada8_6eb0_4230_a083_b2ab094d2961_mw9cafad09_6002_46e1_8336_bb91c3716d70"] * u[73]

    # Species:   id = mwe2fff28d_182c_4a1c_9882_f17774c0958a; name = EGF; affected by kineticLaw
    du[1] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwa67e40c1_693d_4214_adc8_b2f2b71cef12))

    # Species:   id = mw93907b2d_53db_4080_9e3f_3eb304441ab9; name = EGFR; affected by kineticLaw
    du[2] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwa67e40c1_693d_4214_adc8_b2f2b71cef12) + (1.0 * reaction_mw47dee769_daa0_4af4_978a_5ab17e504c2f))

    # Species:   id = mw7eacabf9_d68c_491a_aba2_ec0809a8ecc8; name = EGF-EGFR; affected by kineticLaw
    du[3] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwa67e40c1_693d_4214_adc8_b2f2b71cef12) + (-1.0 * reaction_mw877cd1e3_b48b_42e8_ab23_682dd893fd9d) + (-1.0 * reaction_mw877cd1e3_b48b_42e8_ab23_682dd893fd9d))

    # Species:   id = mwa8f2e7b2_0927_4ab4_a817_dddc43bb4fa3; name = EGF-EGFR2; affected by kineticLaw
    du[4] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw877cd1e3_b48b_42e8_ab23_682dd893fd9d) + (-1.0 * reaction_mw413c6d45_ab23_4d3e_87b3_a8ed4629b923) + (1.0 * reaction_mw9544e67b_b6d0_4941_b7e0_ecd4f400a335) + (1.0 * reaction_mw7bb43f0a_c87e_41ff_8a43_cdf45c8f05e6) + (1.0 * reaction_mw4f89bf6c_8691_41a6_a1ac_13e6aa8c4b93) + (1.0 * reaction_mw642ac312_2ee7_4e66_8f3e_e2da2bb6412a))

    # Species:   id = mwbfcf6773_1915_432c_b1d2_1f246094cc74; name = pEGF-EGFR2; affected by kineticLaw
    du[5] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw413c6d45_ab23_4d3e_87b3_a8ed4629b923) + (-1.0 * reaction_mwf61e086d_0345_4d4c_b91d_0b105e543d04) + (-1.0 * reaction_mw91f49311_efdc_47c6_b8b8_a619e042d644) + (1.0 * reaction_mw486c5261_3d03_4589_a1e9_978b62ad2dfe) + (-1.0 * reaction_mw0e459167_515b_4c4d_8b67_bf0a5b3e9d61) + (-1.0 * reaction_mwd0d92dd4_81b7_4385_bfd7_5de82e193ecd) + (-1.0 * reaction_mw0a51fbf0_409b_4b45_b4ac_0220af4c4e3c) + (1.0 * reaction_mwcf9f1b1d_e19a_4fa8_85ba_8f17e2cec730) + (1.0 * reaction_mw4685274a_2b55_429f_927f_3fd863592af6) + (-1.0 * reaction_mw85e457d1_73f8_4236_bb61_a128d300003f) + (-1.0 * reaction_mw77484632_4e33_468a_9937_24e9bfd0e17d) + (1.0 * reaction_mwd3a36af9_3ccc_4bb1_9867_3b9823ba4ac8) + (-1.0 * reaction_mwe8647e48_f4a9_40f4_9b32_f89ded572e01) + (1.0 * reaction_mw65b9e026_bc6c_4c94_8b37_8b9acdf50c8a) + (-1.0 * reaction_mw1c9d29fa_bff4_4d2f_9d5f_f1791e4882a3))

    # Species:   id = mw19122f7d_f92e_4dc0_922f_6b681db65b0b; name = cbl; affected by kineticLaw
    du[6] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwbd8a133e_1b70_44e8_bef8_78b14141166b) + (1.0 * reaction_mw363a5271_1f51_4d5e_87a7_42ea25cb5657) + (-1.0 * reaction_mw6bee0112_92dc_4169_9109_2633772b3aa4) + (1.0 * reaction_mweb93165f_cf03_48f1_b035_59d79e324314) + (-1.0 * reaction_mw85e457d1_73f8_4236_bb61_a128d300003f) + (1.0 * reaction_mwc9b3b248_3290_452a_9b7c_8fdada3e6687) + (-1.0 * reaction_mwcb637bf1_7618_4d8a_ab5c_399145ecf1df) + (1.0 * reaction_mw0dd5a91d_d76c_494e_9dd6_57f2836aaa19) + (-1.0 * reaction_mwb205f533_4013_406b_8a4b_691ec3949555))

    # Species:   id = mw3c2e1b43_29ca_491a_93e9_c723a993d6fb; name = Shc; affected by kineticLaw
    du[7] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwf61e086d_0345_4d4c_b91d_0b105e543d04) + (1.0 * reaction_mweda6a945_fb5d_4d99_9958_11b2b2840308) + (1.0 * reaction_mwd4bf58ea_70c9_43ea_a831_1fcde130ba28))

    # Species:   id = mw5198d3c2_879c_4f0d_b4f8_cd40efe0b1cf; name = pEGF-EGFR2-Shc; affected by kineticLaw
    du[8] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwf61e086d_0345_4d4c_b91d_0b105e543d04) + (-1.0 * reaction_mw974c39f5_b82e_44b3_abec_7a724f46c526))

    # Species:   id = mwe57c3282_5935_405c_8c0b_7fadb7a5de17; name = SHP; affected by kineticLaw
    du[9] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw91f49311_efdc_47c6_b8b8_a619e042d644) + (1.0 * reaction_mw9544e67b_b6d0_4941_b7e0_ecd4f400a335) + (-1.0 * reaction_mw2cf8a809_63d8_4717_91fc_070516e6f3db) + (1.0 * reaction_mweda6a945_fb5d_4d99_9958_11b2b2840308) + (-1.0 * reaction_mw03998474_934b_4e4a_8c0c_ca359e402ac2) + (1.0 * reaction_mw7bb43f0a_c87e_41ff_8a43_cdf45c8f05e6) + (-1.0 * reaction_mwc52e0f9b_1e0c_46ca_8d18_f05ef4a080cb) + (1.0 * reaction_mw4f89bf6c_8691_41a6_a1ac_13e6aa8c4b93) + (-1.0 * reaction_mwc5aae1f8_52e4_4bcd_b044_3768f90b7b19) + (1.0 * reaction_mw642ac312_2ee7_4e66_8f3e_e2da2bb6412a))

    # Species:   id = mw954e8fcb_ac0a_459d_8878_f19080208a17; name = pEGF-EGFR2-SHP2; affected by kineticLaw
    du[10] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw91f49311_efdc_47c6_b8b8_a619e042d644) + (-1.0 * reaction_mw9544e67b_b6d0_4941_b7e0_ecd4f400a335))

    # Species:   id = mwa98802cb_c977_4fe0_9e67_5000904c2c36; name = pEGF-EGFR2-pShc; affected by kineticLaw
    du[11] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw974c39f5_b82e_44b3_abec_7a724f46c526) + (-1.0 * reaction_mw486c5261_3d03_4589_a1e9_978b62ad2dfe) + (-1.0 * reaction_mw4817365e_a33b_451f_bee1_de748377ede2) + (-1.0 * reaction_mw23a29b42_9813_4e46_b8ae_966e3215e6dc))

    # Species:   id = mwa0349407_8187_48fc_9e94_5698ccc4e06d; name = pShc; affected by kineticLaw
    du[12] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw486c5261_3d03_4589_a1e9_978b62ad2dfe) + (-1.0 * reaction_mw2cf8a809_63d8_4717_91fc_070516e6f3db) + (-1.0 * reaction_mwd4bf58ea_70c9_43ea_a831_1fcde130ba28) + (1.0 * reaction_mw7bb43f0a_c87e_41ff_8a43_cdf45c8f05e6) + (1.0 * reaction_mwcf9f1b1d_e19a_4fa8_85ba_8f17e2cec730) + (1.0 * reaction_mw363a5271_1f51_4d5e_87a7_42ea25cb5657))

    # Species:   id = mwf9999977_6f0e_4e35_9b73_75587f3448e9; name = pShc-SHP2; affected by kineticLaw
    du[13] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw2cf8a809_63d8_4717_91fc_070516e6f3db) + (-1.0 * reaction_mweda6a945_fb5d_4d99_9958_11b2b2840308))

    # Species:   id = mwf430a579_ecbf_48ba_80c2_06e455808f2a; name = Grb2; affected by kineticLaw
    du[14] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw4817365e_a33b_451f_bee1_de748377ede2) + (1.0 * reaction_mw7bb43f0a_c87e_41ff_8a43_cdf45c8f05e6) + (-1.0 * reaction_mwc5f121dc_d27d_4c3d_90f2_67d0adaf144a) + (-1.0 * reaction_mw0e459167_515b_4c4d_8b67_bf0a5b3e9d61) + (1.0 * reaction_mw4f89bf6c_8691_41a6_a1ac_13e6aa8c4b93) + (1.0 * reaction_mwcf9f1b1d_e19a_4fa8_85ba_8f17e2cec730) + (1.0 * reaction_mw4685274a_2b55_429f_927f_3fd863592af6))

    # Species:   id = mw504578d8_96c3_471f_8a7e_8c14e7535d3d; name = pEGF-EGFR2-pShc-Grb2; affected by kineticLaw
    du[15] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw4817365e_a33b_451f_bee1_de748377ede2) + (-1.0 * reaction_mw03998474_934b_4e4a_8c0c_ca359e402ac2) + (-1.0 * reaction_mwd9262331_e35a_4614_943a_89bcf8a492e3))

    # Species:   id = mw45ab688a_6467_4a3e_a779_2118fa84d69e; name = pEGF-EGFR2-pShc-Grb2-SHP2; affected by kineticLaw
    du[16] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw03998474_934b_4e4a_8c0c_ca359e402ac2) + (-1.0 * reaction_mw7bb43f0a_c87e_41ff_8a43_cdf45c8f05e6))

    # Species:   id = mw9dcaa655_a755_426e_a3fa_1ad7c3c45575; name = SOS; affected by kineticLaw
    du[17] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwd9262331_e35a_4614_943a_89bcf8a492e3) + (-1.0 * reaction_mwc5f121dc_d27d_4c3d_90f2_67d0adaf144a) + (-1.0 * reaction_mw35f71989_f89b_4440_b1a4_ebc7b4cc18b2) + (1.0 * reaction_mw8e331e43_16b4_478d_880b_d5a3244540e4))

    # Species:   id = mwfbda4e09_0cbb_49bc_ae69_f88b7a79ed21; name = pEGF-EGFR2-pShc-Grb2-SOS; affected by kineticLaw
    du[18] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwd9262331_e35a_4614_943a_89bcf8a492e3) + (1.0 * reaction_mw23a29b42_9813_4e46_b8ae_966e3215e6dc) + (-1.0 * reaction_mwbb77e3d6_6065_4344_9361_e30c03514f4e) + (1.0 * reaction_mw0bcfad86_59b9_42ff_bcb7_fbb44845049d) + (-1.0 * reaction_mw8dec1159_1925_45d9_af25_3cb709a5017c) + (-1.0 * reaction_mwbd8a133e_1b70_44e8_bef8_78b14141166b))

    # Species:   id = mwb1bc2058_e6d8_4680_9e6c_d27bb366cde0; name = pEGF-EGFR2-pShc-Grb2-SOS-cbl; affected by kineticLaw
    du[19] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwbd8a133e_1b70_44e8_bef8_78b14141166b) + (-1.0 * reaction_mw3a87ca5a_845d_4ac4_8806_e343cbbfc630))

    # Species:   id = mw1093b3af_1864_4ba3_a541_6009a9921282; name = Grb2-SOS; affected by kineticLaw
    du[20] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwc5f121dc_d27d_4c3d_90f2_67d0adaf144a) + (-1.0 * reaction_mw23a29b42_9813_4e46_b8ae_966e3215e6dc) + (-1.0 * reaction_mwd0d92dd4_81b7_4385_bfd7_5de82e193ecd) + (1.0 * reaction_mw363a5271_1f51_4d5e_87a7_42ea25cb5657) + (1.0 * reaction_mweb93165f_cf03_48f1_b035_59d79e324314))

    # Species:   id = mwd9462e5b_a272_4b66_ab66_fde9266b1a43; name = pEGF-EGFR2-Grb2; affected by kineticLaw
    du[21] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw0e459167_515b_4c4d_8b67_bf0a5b3e9d61) + (-1.0 * reaction_mwc52e0f9b_1e0c_46ca_8d18_f05ef4a080cb) + (-1.0 * reaction_mw35f71989_f89b_4440_b1a4_ebc7b4cc18b2))

    # Species:   id = mw925b938a_fe73_4664_ba6f_e72e57780891; name = pEGF-EGFR2-Grb2-SHP2; affected by kineticLaw
    du[22] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwc52e0f9b_1e0c_46ca_8d18_f05ef4a080cb) + (-1.0 * reaction_mw4f89bf6c_8691_41a6_a1ac_13e6aa8c4b93))

    # Species:   id = mwf8cc7834_bf4f_4ccd_8235_d0890badf0f6; name = pEGF-EGFR2-Grb2-SOS; affected by kineticLaw
    du[23] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw35f71989_f89b_4440_b1a4_ebc7b4cc18b2) + (1.0 * reaction_mwd0d92dd4_81b7_4385_bfd7_5de82e193ecd) + (1.0 * reaction_mwe9b50ac7_dac3_4eba_b1db_b3fd392d8fb7) + (-1.0 * reaction_mw934c3638_603e_4ff0_a763_68f9405fa01f) + (-1.0 * reaction_mwa5c135b4_77e2_4411_98e1_2000c39d4b30) + (-1.0 * reaction_mw6bee0112_92dc_4169_9109_2633772b3aa4))

    # Species:   id = mw481cd12b_61ba_44e5_93bf_8b88c6c4a4e7; name = pEGF-EGFR2-Grb2-SOS-cbl; affected by kineticLaw
    du[24] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw6bee0112_92dc_4169_9109_2633772b3aa4) + (-1.0 * reaction_mwbac9e6ff_2df1_45eb_b3f4_4cae74c64014))

    # Species:   id = mw8f5a7b5c_ca4c_4a4c_85b1_e5d640c426bf; name = Ras-GDP; affected by kineticLaw
    du[25] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwbb77e3d6_6065_4344_9361_e30c03514f4e) + (1.0 * reaction_mw921ee820_1dbb_4b5f_866c_87da620d8f89) + (-1.0 * reaction_mw934c3638_603e_4ff0_a763_68f9405fa01f) + (1.0 * reaction_mwf31259aa_32b7_4104_be70_045297b9a512) + (1.0 * reaction_mw652570eb_c9d3_499b_b877_61d360b10980))

    # Species:   id = mwf40d6176_abfc_4a30_886f_83a19fcffc48; name = pEGF-EGFR2-pShc-Grb2-SOS-Ras-GDP; affected by kineticLaw
    du[26] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwbb77e3d6_6065_4344_9361_e30c03514f4e) + (-1.0 * reaction_mw0bcfad86_59b9_42ff_bcb7_fbb44845049d))

    # Species:   id = mwa54a9c38_c98b_45e5_8432_4119fb777e44; name = Ras-GTP; affected by kineticLaw
    du[27] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw921ee820_1dbb_4b5f_866c_87da620d8f89) + (1.0 * reaction_mw0bcfad86_59b9_42ff_bcb7_fbb44845049d) + (1.0 * reaction_mwe9b50ac7_dac3_4eba_b1db_b3fd392d8fb7) + (-1.0 * reaction_mw3c617363_649b_4460_a694_36f7a3127a62) + (-1.0 * reaction_mw33baddbd_a23f_45bb_b126_0ba60bbf6c53) + (-1.0 * reaction_mw584a64d0_560a_4297_9882_80cb4eff73f3) + (1.0 * reaction_mw42c97708_4f85_45a8_9141_d0ae529409ca))

    # Species:   id = mw28464aad_8013_4a23_ae09_a406954859a6; name = pEGF-EGFR2-Grb2-SOS-Ras-GDP; affected by kineticLaw
    du[28] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwe9b50ac7_dac3_4eba_b1db_b3fd392d8fb7) + (1.0 * reaction_mw934c3638_603e_4ff0_a763_68f9405fa01f))

    # Species:   id = mw7cff9a0e_094d_498e_bf7f_7b162c61d63a; name = Ras-GAP; affected by kineticLaw
    du[29] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw3c617363_649b_4460_a694_36f7a3127a62) + (1.0 * reaction_mwf31259aa_32b7_4104_be70_045297b9a512) + (-1.0 * reaction_mw0a51fbf0_409b_4b45_b4ac_0220af4c4e3c) + (1.0 * reaction_mw642ac312_2ee7_4e66_8f3e_e2da2bb6412a))

    # Species:   id = mwdf82303e_323f_4c51_a858_56a59233cd98; name = Ras-GTP-Ras-GAP; affected by kineticLaw
    du[30] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw3c617363_649b_4460_a694_36f7a3127a62) + (-1.0 * reaction_mwf31259aa_32b7_4104_be70_045297b9a512))

    # Species:   id = mwd39388fd_4f85_4d1c_b2a3_37857c595a2d; name = pEGF-EGFR2-Ras-GAP; affected by kineticLaw
    du[31] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw0a51fbf0_409b_4b45_b4ac_0220af4c4e3c) + (-1.0 * reaction_mw33baddbd_a23f_45bb_b126_0ba60bbf6c53) + (1.0 * reaction_mw652570eb_c9d3_499b_b877_61d360b10980) + (-1.0 * reaction_mwc5aae1f8_52e4_4bcd_b044_3768f90b7b19))

    # Species:   id = mwd7bf31ba_b05c_4c45_bb2f_6a2468a2a507; name = pEGF-EGFR2-Ras-GAP-Ras-GTP; affected by kineticLaw
    du[32] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw33baddbd_a23f_45bb_b126_0ba60bbf6c53) + (-1.0 * reaction_mw652570eb_c9d3_499b_b877_61d360b10980))

    # Species:   id = mwbf5cb039_b830_4282_aa22_a3dda6272ec1; name = pEGF-EGFR2-Ras-GAP-SHP2; affected by kineticLaw
    du[33] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwc5aae1f8_52e4_4bcd_b044_3768f90b7b19) + (-1.0 * reaction_mw642ac312_2ee7_4e66_8f3e_e2da2bb6412a))

    # Species:   id = mw66ac98c4_7e7b_4071_954d_43eb17584220; name = Raf1; affected by kineticLaw
    du[34] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw584a64d0_560a_4297_9882_80cb4eff73f3) + (1.0 * reaction_mw87711dc1_43d7_40fc_b9e9_a24e2f92419d))

    # Species:   id = mw83de7813_4941_45a6_a320_a551165bf22a; name = Raf1-Ras-GTP; affected by kineticLaw
    du[35] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw584a64d0_560a_4297_9882_80cb4eff73f3) + (-1.0 * reaction_mw42c97708_4f85_45a8_9141_d0ae529409ca))

    # Species:   id = mwaff92910_ed3d_40b9_a29c_e4866167e828; name = Raf1active; affected by kineticLaw
    du[36] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw42c97708_4f85_45a8_9141_d0ae529409ca) + (-1.0 * reaction_mwaa65a34e_fabf_4d6d_ae0b_f1d08b068f33) + (1.0 * reaction_mw1bd186cf_4762_480a_b70d_d7a775462398) + (-1.0 * reaction_mwf5573ddf_ad7f_478a_a784_557a9cddaaf2) + (1.0 * reaction_mwb49058ff_2997_4187_abe7_4dce4ccf6ff4) + (-1.0 * reaction_mw9c208e18_c70d_4231_af0b_ad17cd0bba2d) + (-1.0 * reaction_mw950485f2_4463_4309_a4e4_cc81d16ffb7f) + (1.0 * reaction_mw62f71309_e066_47d2_9b99_01f78a51c218))

    # Species:   id = mw0834731b_0477_4217_a53b_30cef851191b; name = MEK; affected by kineticLaw
    du[37] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwaa65a34e_fabf_4d6d_ae0b_f1d08b068f33) + (1.0 * reaction_mwa4b69c77_6226_46da_b78c_3e6027d0be41))

    # Species:   id = mw4628f984_eb87_4922_9760_4975095ce6eb; name = Raf1active-MEK; affected by kineticLaw
    du[38] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwaa65a34e_fabf_4d6d_ae0b_f1d08b068f33) + (-1.0 * reaction_mw1bd186cf_4762_480a_b70d_d7a775462398))

    # Species:   id = mw9b25f809_18a1_4c14_8f4b_cf18e6d93c28; name = pMEK; affected by kineticLaw
    du[39] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw1bd186cf_4762_480a_b70d_d7a775462398) + (-1.0 * reaction_mwf5573ddf_ad7f_478a_a784_557a9cddaaf2) + (1.0 * reaction_mw40950d59_1012_4361_8418_73e25758e367) + (-1.0 * reaction_mwbfa79c95_487d_4c6f_b437_9e579451a419))

    # Species:   id = mw12ba4000_d452_420c_be63_96d2848aca32; name = Raf1active-pMEK; affected by kineticLaw
    du[40] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwf5573ddf_ad7f_478a_a784_557a9cddaaf2) + (-1.0 * reaction_mwb49058ff_2997_4187_abe7_4dce4ccf6ff4))

    # Species:   id = mwf816df4c_4593_4d23_990f_0d7c15ddde5d; name = ppMEK; affected by kineticLaw
    du[41] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwb49058ff_2997_4187_abe7_4dce4ccf6ff4) + (-1.0 * reaction_mw8301b154_9463_4516_b4c5_c8f8b68691fe) + (1.0 * reaction_mwf95f743d_6108_49fe_8ffd_bdcc1a9f9a8d) + (-1.0 * reaction_mw51d9d6b8_f0c0_4763_9d11_9be61b5cf5c9) + (1.0 * reaction_mw6fd24d16_f57d_46c6_82f5_3f00759fa16b) + (-1.0 * reaction_mw4b445876_bdce_42d0_867b_fd3c74128a6b))

    # Species:   id = mw7e23b961_186b_47a0_a8b5_5e9957766792; name = ERK; affected by kineticLaw
    du[42] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw8301b154_9463_4516_b4c5_c8f8b68691fe) + (1.0 * reaction_mwcc31b497_6c50_446c_bbc2_6c5739507252))

    # Species:   id = mwcedf8ecd_67bd_4b91_aa04_d58782dec2a4; name = ppMEK-ERK; affected by kineticLaw
    du[43] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw8301b154_9463_4516_b4c5_c8f8b68691fe) + (-1.0 * reaction_mwf95f743d_6108_49fe_8ffd_bdcc1a9f9a8d))

    # Species:   id = mwcc894c94_0ddf_42cc_913e_cdcc4d471d94; name = pERK; affected by kineticLaw
    du[44] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwf95f743d_6108_49fe_8ffd_bdcc1a9f9a8d) + (-1.0 * reaction_mw51d9d6b8_f0c0_4763_9d11_9be61b5cf5c9) + (1.0 * reaction_mw61305f93_7b2d_4a2d_8d16_f7be026d8671) + (-1.0 * reaction_mw1d8c2435_bb85_4352_a25f_82033250579e))

    # Species:   id = mw6cb74b27_ffef_49bb_8ffb_622d552caa9e; name = ppMEK-pERK; affected by kineticLaw
    du[45] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw51d9d6b8_f0c0_4763_9d11_9be61b5cf5c9) + (-1.0 * reaction_mw6fd24d16_f57d_46c6_82f5_3f00759fa16b))

    # Species:   id = mwd784228d_0cb5_468a_ac70_02d8f04b3d9c; name = ppERK; affected by kineticLaw
    du[46] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw6fd24d16_f57d_46c6_82f5_3f00759fa16b) + (-1.0 * reaction_mwf8bb22e2_5aa3_4c25_a022_a266b1856a48) + (-1.0 * reaction_mw8dec1159_1925_45d9_af25_3cb709a5017c) + (1.0 * reaction_mwcf9f1b1d_e19a_4fa8_85ba_8f17e2cec730) + (-1.0 * reaction_mwa5c135b4_77e2_4411_98e1_2000c39d4b30) + (1.0 * reaction_mw4685274a_2b55_429f_927f_3fd863592af6))

    # Species:   id = mwbaaeb210_4806_4076_9d60_219f4ed945b6; name = Pase; affected by kineticLaw
    du[47] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw9c208e18_c70d_4231_af0b_ad17cd0bba2d) + (1.0 * reaction_mw87711dc1_43d7_40fc_b9e9_a24e2f92419d))

    # Species:   id = mw19a33ad5_5ba4_46c7_84eb_c1287f02bcd5; name = Raf1active-Pase; affected by kineticLaw
    du[48] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw9c208e18_c70d_4231_af0b_ad17cd0bba2d) + (-1.0 * reaction_mw87711dc1_43d7_40fc_b9e9_a24e2f92419d))

    # Species:   id = mwf9e2a044_7774_400b_a74e_a111b4a21f30; name = Pase2; affected by kineticLaw
    du[49] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw4b445876_bdce_42d0_867b_fd3c74128a6b) + (1.0 * reaction_mw40950d59_1012_4361_8418_73e25758e367) + (-1.0 * reaction_mwbfa79c95_487d_4c6f_b437_9e579451a419) + (1.0 * reaction_mwa4b69c77_6226_46da_b78c_3e6027d0be41))

    # Species:   id = mwcb572fe2_c3ac_40e7_8141_da7d55fce18a; name = ppMEK-Pase2; affected by kineticLaw
    du[50] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw4b445876_bdce_42d0_867b_fd3c74128a6b) + (-1.0 * reaction_mw40950d59_1012_4361_8418_73e25758e367))

    # Species:   id = mwa0acc0ac_5fac_4a42_a3be_e36db44994b0; name = pMEK-Pase2; affected by kineticLaw
    du[51] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwbfa79c95_487d_4c6f_b437_9e579451a419) + (-1.0 * reaction_mwa4b69c77_6226_46da_b78c_3e6027d0be41))

    # Species:   id = mwd087f76b_65dc_47f1_ba21_c43774457686; name = Pase3; affected by kineticLaw
    du[52] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwf8bb22e2_5aa3_4c25_a022_a266b1856a48) + (1.0 * reaction_mw61305f93_7b2d_4a2d_8d16_f7be026d8671) + (1.0 * reaction_mwcc31b497_6c50_446c_bbc2_6c5739507252) + (-1.0 * reaction_mw1d8c2435_bb85_4352_a25f_82033250579e))

    # Species:   id = mw35f5adaa_d1c0_433c_817d_76e317f4cb15; name = pERK-Pase3; affected by kineticLaw
    du[53] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwcc31b497_6c50_446c_bbc2_6c5739507252) + (1.0 * reaction_mw1d8c2435_bb85_4352_a25f_82033250579e))

    # Species:   id = mwa7e3103a_6394_472c_b0f4_8ed527f68604; name = ppERK-Pase3; affected by kineticLaw
    du[54] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwf8bb22e2_5aa3_4c25_a022_a266b1856a48) + (-1.0 * reaction_mw61305f93_7b2d_4a2d_8d16_f7be026d8671))

    # Species:   id = mw5babe3d5_a9af_4dfd_ac01_35474ef64af2; name = ppERK-pEGF-EGFR2-pShc-Grb2-SOS; affected by kineticLaw
    du[55] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw8dec1159_1925_45d9_af25_3cb709a5017c) + (-1.0 * reaction_mwcf9f1b1d_e19a_4fa8_85ba_8f17e2cec730))

    # Species:   id = mw31ac308f_da36_4f73_830f_67f3e5b945d9; name = pSOS; affected by kineticLaw
    du[56] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwcf9f1b1d_e19a_4fa8_85ba_8f17e2cec730) + (1.0 * reaction_mw4685274a_2b55_429f_927f_3fd863592af6) + (-1.0 * reaction_mw8e331e43_16b4_478d_880b_d5a3244540e4))

    # Species:   id = mw31261227_9cd6_4059_a0bb_04dbf4888080; name = ppERK-pEGF-EGFR2-Grb2-SOS; affected by kineticLaw
    du[57] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwa5c135b4_77e2_4411_98e1_2000c39d4b30) + (-1.0 * reaction_mw4685274a_2b55_429f_927f_3fd863592af6))

    # Species:   id = mw0a0ca6ba_cb28_44c7_a0c0_1593cb720966; name = ProEGFR; affected by kineticLaw
    du[58] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw47dee769_daa0_4af4_978a_5ab17e504c2f))

    # Species:   id = mw06b8aada_c92a_48eb_8ee7_af3778cfe62f; name = pEGF-EGFR2-pShc-Grb2-SOS-cbl-EPn; affected by kineticLaw
    du[59] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw3a87ca5a_845d_4ac4_8806_e343cbbfc630) + (-1.0 * reaction_mw363a5271_1f51_4d5e_87a7_42ea25cb5657))

    # Species:   id = mwb2366216_0b3c_4f28_8303_fec92c68dd57; name = EPn; affected by kineticLaw
    du[60] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw3a87ca5a_845d_4ac4_8806_e343cbbfc630) + (1.0 * reaction_mw363a5271_1f51_4d5e_87a7_42ea25cb5657) + (-1.0 * reaction_mwbac9e6ff_2df1_45eb_b3f4_4cae74c64014) + (1.0 * reaction_mweb93165f_cf03_48f1_b035_59d79e324314) + (-1.0 * reaction_mw6b159c8f_eee0_4337_b711_2e230c9e2cf6) + (1.0 * reaction_mwc9b3b248_3290_452a_9b7c_8fdada3e6687) + (-1.0 * reaction_mw401dde7e_c0a1_4780_b6cc_8f98681c862e) + (1.0 * reaction_mw0dd5a91d_d76c_494e_9dd6_57f2836aaa19) + (-1.0 * reaction_mw602726ea_89ee_41b8_bda6_e2811bb42c1d) + (1.0 * reaction_mwfab3a9ec_b094_44f0_bd59_12ac56ca1c99))

    # Species:   id = mw1d5948e7_5504_4224_9d71_227911b4f1ee; name = pEGF-EGFR2-Grb2-SOS-cbl-EPn; affected by kineticLaw
    du[61] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwbac9e6ff_2df1_45eb_b3f4_4cae74c64014) + (-1.0 * reaction_mweb93165f_cf03_48f1_b035_59d79e324314))

    # Species:   id = mwec1b368b_8f73_47eb_9636_9956389836eb; name = pEGF-EGFR2-cbl; affected by kineticLaw
    du[62] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw85e457d1_73f8_4236_bb61_a128d300003f) + (-1.0 * reaction_mw6b159c8f_eee0_4337_b711_2e230c9e2cf6))

    # Species:   id = mwa455ec7e_1a12_4659_95a2_a5695d09ca60; name = pEGF-EGFR2-cbl-EPn; affected by kineticLaw
    du[63] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw6b159c8f_eee0_4337_b711_2e230c9e2cf6) + (-1.0 * reaction_mwc9b3b248_3290_452a_9b7c_8fdada3e6687))

    # Species:   id = mw2ba1db9a_4483_44fa_a3a2_b4a5ea66898c; name = PI3K; affected by kineticLaw
    du[64] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw77484632_4e33_468a_9937_24e9bfd0e17d) + (1.0 * reaction_mwd15926b3_069a_4b16_a6fc_c0c15083d621) + (1.0 * reaction_mwfab3a9ec_b094_44f0_bd59_12ac56ca1c99))

    # Species:   id = mw0dc4e5eb_4366_4799_bebc_cfcffe5c06f5; name = pEGF-EGFR2-PI3K; affected by kineticLaw
    du[65] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw77484632_4e33_468a_9937_24e9bfd0e17d) + (-1.0 * reaction_mw2c5858f3_0988_49b0_a94a_057853b84e91) + (-1.0 * reaction_mwd3a36af9_3ccc_4bb1_9867_3b9823ba4ac8) + (-1.0 * reaction_mwb205f533_4013_406b_8a4b_691ec3949555))

    # Species:   id = mw1e591998_65c0_484e_8a3b_537a38d94de1; name = pEGF-EGFR2-pPI3K; affected by kineticLaw
    du[66] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw2c5858f3_0988_49b0_a94a_057853b84e91))

    # Species:   id = mw78e207c4_4faf_4b48_8e22_1ee666e9cc4c; name = pPI3K; affected by kineticLaw
    du[67] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwd3a36af9_3ccc_4bb1_9867_3b9823ba4ac8) + (-1.0 * reaction_mw9f000f29_2512_4d4a_9dd9_e59aaf296d31) + (-1.0 * reaction_mw3a5e0932_d50f_4fe6_b8cb_0ad649f305b0) + (1.0 * reaction_mw5dcc8719_3180_4bd0_8797_08e256131961))

    # Species:   id = mwfc4a9c3d_3ebb_4033_8b7d_f4d7613d2078; name = TP4; affected by kineticLaw
    du[68] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw9f000f29_2512_4d4a_9dd9_e59aaf296d31) + (1.0 * reaction_mwd15926b3_069a_4b16_a6fc_c0c15083d621))

    # Species:   id = mwbd6bb050_89bd_41df_8cea_d2e1fb77bafe; name = TP4-pPI3K; affected by kineticLaw
    du[69] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw9f000f29_2512_4d4a_9dd9_e59aaf296d31) + (-1.0 * reaction_mw837b5ad7_4a8c_4c55_94ff_0fdd63048044))

    # Species:   id = mw7033dfd6_53c5_433b_a132_f8cb34dea20f; name = TP4-PI3K; affected by kineticLaw
    du[70] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw837b5ad7_4a8c_4c55_94ff_0fdd63048044) + (-1.0 * reaction_mwd15926b3_069a_4b16_a6fc_c0c15083d621))

    # Species:   id = mwb561d9f3_a9ed_4bdb_8d40_87be5cc3237a; name = PIP2; affected by kineticLaw
    du[71] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw3a5e0932_d50f_4fe6_b8cb_0ad649f305b0) + (1.0 * reaction_mw4fceada8_6eb0_4230_a083_b2ab094d2961))

    # Species:   id = mw014cc419_b720_4b90_9192_2ec6e706c87d; name = pPI3K-PIP2; affected by kineticLaw
    du[72] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw3a5e0932_d50f_4fe6_b8cb_0ad649f305b0) + (-1.0 * reaction_mw5dcc8719_3180_4bd0_8797_08e256131961))

    # Species:   id = mwd7f41594_8377_4e2e_9528_45d5a82ffdb4; name = PIP3; affected by kineticLaw
    du[73] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw5dcc8719_3180_4bd0_8797_08e256131961) + (-1.0 * reaction_mw376b0685_ef73_4fcc_94af_2ada24cf8a8b) + (1.0 * reaction_mw12311a84_3f8d_40c6_8b14_961a8a58d1b6) + (-1.0 * reaction_mw4fceada8_6eb0_4230_a083_b2ab094d2961))

    # Species:   id = mwcef73e0e_d195_4077_ae71_723664ee1602; name = Akt; affected by kineticLaw
    du[74] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw376b0685_ef73_4fcc_94af_2ada24cf8a8b) + (1.0 * reaction_mw2698f402_d00b_451e_8b22_93a322fe9a92))

    # Species:   id = mw62bf5275_ce02_4e86_b3b6_3f87a335e1de; name = Aktm; affected by kineticLaw
    du[75] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw376b0685_ef73_4fcc_94af_2ada24cf8a8b) + (-1.0 * reaction_mwcc7cfa9c_4945_403a_938e_b237c371a5ef) + (1.0 * reaction_mw362ca1b3_224a_42fb_a14b_6ff467748a5e))

    # Species:   id = mw6e01967b_3e2a_433d_bec6_9f9cf3ba243c; name = PDK1; affected by kineticLaw
    du[76] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwcc7cfa9c_4945_403a_938e_b237c371a5ef) + (1.0 * reaction_mw31369230_1f14_45bd_be02_a44a275c6e31))

    # Species:   id = mw6353aa36_d4a4_4254_8a1f_1f7f571d4233; name = Aktm-PDK1; affected by kineticLaw
    du[77] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwcc7cfa9c_4945_403a_938e_b237c371a5ef) + (-1.0 * reaction_mw98da32e0_b061_40c5_9d32_40744134f3fa) + (1.0 * reaction_mw4a334f7d_9bce_4690_b623_a427ed66a174))

    # Species:   id = mwc1935afc_56b1_4a87_923c_ae6d82455d80; name = pAktm-PDK1; affected by kineticLaw
    du[78] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw98da32e0_b061_40c5_9d32_40744134f3fa) + (-1.0 * reaction_mw31369230_1f14_45bd_be02_a44a275c6e31) + (-1.0 * reaction_mw3994e898_7232_4b70_9c58_b3476e8655f5))

    # Species:   id = mw3d81860d_d786_4fcc_b8bb_64f1a2d7739d; name = pAktm; affected by kineticLaw
    du[79] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw31369230_1f14_45bd_be02_a44a275c6e31) + (-1.0 * reaction_mw12311a84_3f8d_40c6_8b14_961a8a58d1b6) + (-1.0 * reaction_mwc5e0c166_6a3a_4913_9ed1_dafe97bdb371))

    # Species:   id = mw16796ffe_4764_4a9f_942e_149f42c1cd28; name = pAkt; affected by kineticLaw
    du[80] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw12311a84_3f8d_40c6_8b14_961a8a58d1b6) + (-1.0 * reaction_mw028e8b3e_b531_4466_9c3a_e3fcf7fc9be9))

    # Species:   id = mwa6e82fc9_a0ce_461c_93c8_17f3c807c1a1; name = pAkt-Takt; affected by kineticLaw
    du[81] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwf3d393e9_ae09_4eab_a39a_ed0eef0f54bc) + (1.0 * reaction_mw028e8b3e_b531_4466_9c3a_e3fcf7fc9be9))

    # Species:   id = mw236a3250_4c96_4f6e_b94c_ab3d12852801; name = Akt-Takt; affected by kineticLaw
    du[82] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwf3d393e9_ae09_4eab_a39a_ed0eef0f54bc) + (-1.0 * reaction_mw2698f402_d00b_451e_8b22_93a322fe9a92))

    # Species:   id = mw11a8b702_b8ac_4513_b4aa_063e51089812; name = Takt; affected by kineticLaw
    du[83] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw2698f402_d00b_451e_8b22_93a322fe9a92) + (-1.0 * reaction_mw028e8b3e_b531_4466_9c3a_e3fcf7fc9be9) + (-1.0 * reaction_mwc5e0c166_6a3a_4913_9ed1_dafe97bdb371) + (1.0 * reaction_mw362ca1b3_224a_42fb_a14b_6ff467748a5e) + (-1.0 * reaction_mw3994e898_7232_4b70_9c58_b3476e8655f5) + (1.0 * reaction_mw4a334f7d_9bce_4690_b623_a427ed66a174))

    # Species:   id = mw1a0cb97a_b657_430b_963c_92217f643081; name = pAktm-Takt; affected by kineticLaw
    du[84] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwc5e0c166_6a3a_4913_9ed1_dafe97bdb371) + (-1.0 * reaction_mw94b3bae0_4da9_4358_a5ac_a46a5cbf621b))

    # Species:   id = mw9b937ca3_0d82_46d5_8f5a_0f9701002797; name = Aktm-Takt; affected by kineticLaw
    du[85] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw94b3bae0_4da9_4358_a5ac_a46a5cbf621b) + (-1.0 * reaction_mw362ca1b3_224a_42fb_a14b_6ff467748a5e))

    # Species:   id = mw57a44eb0_ace7_4294_905a_219e87d3c281; name = pAktm-PDK1-Takt; affected by kineticLaw
    du[86] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw3994e898_7232_4b70_9c58_b3476e8655f5) + (-1.0 * reaction_mw75acd2d1_3fdf_4c3f_8d99_6d62f825d5e2))

    # Species:   id = mwd746a5d5_5e65_4a4c_9f84_0e4a3cb7d2fc; name = Aktm-PDK1-Takt; affected by kineticLaw
    du[87] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw75acd2d1_3fdf_4c3f_8d99_6d62f825d5e2) + (-1.0 * reaction_mw4a334f7d_9bce_4690_b623_a427ed66a174))

    # Species:   id = mwa6994523_5d45_4000_af0c_3e94073bf183, name = pAkt_total, defined in a rule 	du[88] = u[88]

    # Species:   id = mwdf92bdc0_f426_45b0_9ad0_876521f41312; name = pRaf1active; affected by kineticLaw
    du[89] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw950485f2_4463_4309_a4e4_cc81d16ffb7f) + (-1.0 * reaction_mw62f71309_e066_47d2_9b99_01f78a51c218))

    # Species:   id = mw13abe2a6_9905_40e5_8c23_3fc8834b572a; name = STAT3c; affected by kineticLaw
    du[90] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwe8647e48_f4a9_40f4_9b32_f89ded572e01) + (1.0 * reaction_mwe9988e4a_083c_4f8e_b154_3e599c9307b0) + (-1.0 * reaction_mw177fa7b0_f0be_4c3e_8b47_2ac4e13159a2) + (1.0 * reaction_mwd189238c_e8f9_40be_b4ea_18a42bba1b4f) + (1.0 * reaction_mw0dd5a91d_d76c_494e_9dd6_57f2836aaa19))

    # Species:   id = mw2fd710a6_7fe2_4484_bca6_59c187bade8b; name = pEGF-EGFR2-STAT3c; affected by kineticLaw
    du[91] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwe8647e48_f4a9_40f4_9b32_f89ded572e01) + (-1.0 * reaction_mw65b9e026_bc6c_4c94_8b37_8b9acdf50c8a) + (-1.0 * reaction_mwcb637bf1_7618_4d8a_ab5c_399145ecf1df))

    # Species:   id = mwb6a9aa2c_62e7_410f_9c33_dbe36dfcc4af; name = pSTAT3c; affected by kineticLaw
    du[92] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw65b9e026_bc6c_4c94_8b37_8b9acdf50c8a) + (-1.0 * reaction_mw1c9d29fa_bff4_4d2f_9d5f_f1791e4882a3) + (-1.0 * reaction_mwad97bd5a_3dae_49d9_990b_2e6574740618) + (-1.0 * reaction_mwf8bacf1a_6c1a_49b6_b344_2d3bd404a735) + (-1.0 * reaction_mwf8bacf1a_6c1a_49b6_b344_2d3bd404a735) + (-1.0 * reaction_mw177fa7b0_f0be_4c3e_8b47_2ac4e13159a2))

    # Species:   id = mw341082a0_8017_4cc7_9d00_b1211a196072; name = pEGF-EGFR2-pSTAT3c; affected by kineticLaw
    du[93] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw1c9d29fa_bff4_4d2f_9d5f_f1791e4882a3))

    # Species:   id = mwcea1f1c1_2f85_4af1_98ea_ef14cf580c09; name = PP1; affected by kineticLaw
    du[94] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwad97bd5a_3dae_49d9_990b_2e6574740618) + (1.0 * reaction_mwe9988e4a_083c_4f8e_b154_3e599c9307b0) + (-1.0 * reaction_mwc9b945cf_3a14_4bd9_b253_7064498c75e2) + (1.0 * reaction_mw75c6078f_fb76_4ca9_9fdd_e221e3ba57ad))

    # Species:   id = mwdc34472c_a6f9_4002_951d_e0e8da64eb42; name = pSTAT3c-PP1; affected by kineticLaw
    du[95] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwad97bd5a_3dae_49d9_990b_2e6574740618) + (-1.0 * reaction_mwe9988e4a_083c_4f8e_b154_3e599c9307b0))

    # Species:   id = mw472d5cb9_120e_4f60_bbae_1ae2552837dd; name = pSTAT3c-pSTAT3c-PP1; affected by kineticLaw
    du[96] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwc9b945cf_3a14_4bd9_b253_7064498c75e2) + (-1.0 * reaction_mw75c6078f_fb76_4ca9_9fdd_e221e3ba57ad))

    # Species:   id = mw4f575c55_7dff_45d7_94ad_cda9621d5b63; name = pSTAT3c-pSTAT3c; affected by kineticLaw
    du[97] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwf8bacf1a_6c1a_49b6_b344_2d3bd404a735) + (-1.0 * reaction_mwc9b945cf_3a14_4bd9_b253_7064498c75e2) + (-1.0 * reaction_mwec4127b5_6bcf_4128_aff4_a6b3c470f690))

    # Species:   id = mwd2c465fb_eea7_499a_8ea4_f318a64cb9ee; name = STAT3c-pSTAT3c; affected by kineticLaw
    du[98] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw75c6078f_fb76_4ca9_9fdd_e221e3ba57ad) + (1.0 * reaction_mw177fa7b0_f0be_4c3e_8b47_2ac4e13159a2))

    # Species:   id = mw4110f531_7513_4786_8896_7c9d969ff558; name = pSTAT3n-pSTAT3n; affected by kineticLaw
    du[99] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwec4127b5_6bcf_4128_aff4_a6b3c470f690) + (1.0 * reaction_mw5c806b00_59a1_491e_99a1_2c932b2d5d7a) + (-1.0 * reaction_mw26fdabae_323b_4a78_b134_4c2eb70ea6a7))

    # Species:   id = mwe3fd7f65_b0d1_44d9_b6f3_d2f7d332f664; name = pSTAT3n; affected by kineticLaw
    du[100] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw5c806b00_59a1_491e_99a1_2c932b2d5d7a) + (-1.0 * reaction_mw5c806b00_59a1_491e_99a1_2c932b2d5d7a) + (-1.0 * reaction_mwc38a99c8_74cf_49f2_a16b_f6610ca1a0a7) + (-1.0 * reaction_mw45d92b79_0656_4795_87d0_7a465949ca43))

    # Species:   id = mw0e1be972_fded_4bff_a93d_091ec942485f; name = PP2; affected by kineticLaw
    du[101] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mw26fdabae_323b_4a78_b134_4c2eb70ea6a7) + (1.0 * reaction_mw3b0c171c_6d60_41ca_8193_83cd5e6c188c) + (-1.0 * reaction_mw45d92b79_0656_4795_87d0_7a465949ca43) + (1.0 * reaction_mwb71945c2_03a8_4fad_a995_e1caeee98525))

    # Species:   id = mw0facb8f2_95cf_4ddf_a959_b24ba64f320b; name = pSTAT3n-pSTAT3n-PP2; affected by kineticLaw
    du[102] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw26fdabae_323b_4a78_b134_4c2eb70ea6a7) + (-1.0 * reaction_mw3b0c171c_6d60_41ca_8193_83cd5e6c188c))

    # Species:   id = mw9686f53e_d343_45fd_b441_9c992219546a; name = STAT3n-pSTAT3n; affected by kineticLaw
    du[103] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw3b0c171c_6d60_41ca_8193_83cd5e6c188c) + (1.0 * reaction_mwc38a99c8_74cf_49f2_a16b_f6610ca1a0a7))

    # Species:   id = mw960bddeb_e567_46dd_b2f3_ed5e6a5c7972; name = STAT3n; affected by kineticLaw
    du[104] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((-1.0 * reaction_mwc38a99c8_74cf_49f2_a16b_f6610ca1a0a7) + (1.0 * reaction_mwb71945c2_03a8_4fad_a995_e1caeee98525) + (-1.0 * reaction_mwd189238c_e8f9_40be_b4ea_18a42bba1b4f))

    # Species:   id = mw8c85ff7f_6368_4b11_a2ed_ce83481b55e6; name = pSTAT3n-PP2; affected by kineticLaw
    du[105] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw45d92b79_0656_4795_87d0_7a465949ca43) + (-1.0 * reaction_mwb71945c2_03a8_4fad_a995_e1caeee98525))

    # Species:   id = mw548c81c2_c626_4df8_9177_a1a6fc3d4ce8; name = pEGF-EGFR2-STAT3c-cbl; affected by kineticLaw
    du[106] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwcb637bf1_7618_4d8a_ab5c_399145ecf1df) + (-1.0 * reaction_mw401dde7e_c0a1_4780_b6cc_8f98681c862e))

    # Species:   id = mw142e6dc4_ec15_459d_a184_6b20be04f08d; name = pEGF-EGFR2-STAT3c-cbl-EPn; affected by kineticLaw
    du[107] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw401dde7e_c0a1_4780_b6cc_8f98681c862e) + (-1.0 * reaction_mw0dd5a91d_d76c_494e_9dd6_57f2836aaa19))

    # Species:   id = mw2c47ae3f_06d9_40ec_a252_535db0ae5caa; name = pEGF-EGFR2-PI3K-cbl; affected by kineticLaw
    du[108] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mwb205f533_4013_406b_8a4b_691ec3949555) + (-1.0 * reaction_mw602726ea_89ee_41b8_bda6_e2811bb42c1d))

    # Species:   id = mwd32d108b_49c2_4df2_9b67_d6c6b84f54b9; name = pEGF-EGFR2-PI3K-cbl-EPn; affected by kineticLaw
    du[109] = (1 / (p["compartment_mw1637dd35_5f09_4a8d_bb7f_58717cdf1612"])) * ((1.0 * reaction_mw602726ea_89ee_41b8_bda6_e2811bb42c1d) + (-1.0 * reaction_mwfab3a9ec_b094_44f0_bd59_12ac56ca1c99))

end

u0=zeros(109)
u0[1] = 0.0081967
u0[2] = 0.3
u0[3] = 0.0
u0[4] = 0.0
u0[5] = 0.0
u0[6] = 0.8
u0[7] = 1.0
u0[8] = 0.0
u0[9] = 0.1
u0[10] = 0.0
u0[11] = 0.0
u0[12] = 0.0
u0[13] = 0.0
u0[14] = 1.0
u0[15] = 0.0
u0[16] = 0.0
u0[17] = 0.3
u0[18] = 0.0
u0[19] = 0.0
u0[20] = 0.0
u0[21] = 0.0
u0[22] = 0.0
u0[23] = 0.0
u0[24] = 0.0
u0[25] = 0.15
u0[26] = 0.0
u0[27] = 0.0
u0[28] = 0.0
u0[29] = 0.1
u0[30] = 0.0
u0[31] = 0.0
u0[32] = 0.0
u0[33] = 0.0
u0[34] = 0.5
u0[35] = 0.0
u0[36] = 0.0
u0[37] = 0.68
u0[38] = 0.0
u0[39] = 0.0
u0[40] = 0.0
u0[41] = 0.0
u0[42] = 0.4
u0[43] = 0.0
u0[44] = 0.0
u0[45] = 0.0
u0[46] = 0.0
u0[47] = 0.5
u0[48] = 0.0
u0[49] = 0.02
u0[50] = 0.0
u0[51] = 0.0
u0[52] = 0.002
u0[53] = 0.0
u0[54] = 0.0
u0[55] = 0.0
u0[56] = 0.0
u0[57] = 0.0
u0[58] = 1.0
u0[59] = 0.0
u0[60] = 0.5
u0[61] = 0.0
u0[62] = 0.0
u0[63] = 0.0
u0[64] = 0.2
u0[65] = 0.0
u0[66] = 0.0
u0[67] = 0.0
u0[68] = 0.2
u0[69] = 0.0
u0[70] = 0.0
u0[71] = 0.5
u0[72] = 0.0
u0[73] = 0.0
u0[74] = 0.1
u0[75] = 0.0
u0[76] = 0.1
u0[77] = 0.0
u0[78] = 0.0
u0[79] = 0.0
u0[80] = 0.0
u0[81] = 0.0
u0[82] = 0.0
u0[83] = 0.1
u0[84] = 0.0
u0[85] = 0.0
u0[86] = 0.0
u0[87] = 0.0
u0[88] = 0.0
u0[89] = 0.0
u0[90] = 1.0
u0[91] = 0.0
u0[92] = 0.0
u0[93] = 0.0
u0[94] = 0.5
u0[95] = 0.0
u0[96] = 0.0
u0[97] = 0.0
u0[98] = 0.0
u0[99] = 0.0
u0[100] = 0.0
u0[101] = 0.6
u0[102] = 0.0
u0[103] = 0.0
u0[104] = 0.0
u0[105] = 0.0
u0[106] = 0.0
u0[107] = 0.0
u0[108] = 0.0
u0[109] = 0.0

tspan = (0.0,100.0)

prob = ODEProblem{true,SciMLBase.FullSpecialize}(sbml_model!, u0, tspan, par)

sys = modelingtoolkitize(prob)

sys = structural_simplify(sys)


const to = TimerOutput()

@timeit to "ODEProb No Jac" oprob = ODEProblem{true,SciMLBase.FullSpecialize}(sys, Float64[], tspan, Float64[])
@timeit to "ODEProb DenseJac" densejacprob = ODEProblem{true,SciMLBase.FullSpecialize}(sys, Float64[], tspan, Float64[], jac=true)
ODEProblem with uType Vector{Float64} and tType Float64. In-place: true
timespan: (0.0, 100.0)
u0: 109-element Vector{Float64}:
 0.0081967
 0.3
 0.0
 0.0
 0.0
 0.8
 1.0
 0.0
 0.1
 0.0
 ⋮
 0.6
 0.0
 0.0
 0.0
 0.0
 0.0
 0.0
 0.0
 0.0
@timeit to "ODEProb SparseJac" sparsejacprob = ODEProblem{true,SciMLBase.FullSpecialize}(sys, Float64[], tspan, Float64[], jac=true, sparse=true)
show(to)
──────────────────────────────────────────────────────────────────────────
────
                                      Time                    Allocations  
    
                             ───────────────────────   ────────────────────
────
      Tot / % measured:           39.9s /  96.3%           5.74GiB /  97.6%
    

 Section             ncalls     time    %tot     avg     alloc    %tot     
 avg
 ──────────────────────────────────────────────────────────────────────────
────
 ODEProb No Jac           1    18.3s   47.6%   18.3s   2.93GiB   52.4%  2.9
3GiB
 ODEProb DenseJac         1    14.2s   37.1%   14.2s   1.95GiB   34.8%  1.9
5GiB
 ODEProb SparseJac        1    5.87s   15.3%   5.87s    736MiB   12.8%   73
6MiB
 ──────────────────────────────────────────────────────────────────────────
────
@show numspecies(sys) # Number of ODEs
@show numreactions(sys) # Apprx. number of terms in the ODE
@show length(parameters(sys)) # Number of Parameters
numspecies(sys) = 109
numreactions(sys) = 109
length(parameters(sys)) = 188
188

Picture of the solution

sol = solve(oprob, CVODE_BDF())
plot(sol, legend=false, fmt=:png)

For these benchmarks we will be using the time-series error with these saving points since the final time point is not well-indicative of the solution behavior (capturing the oscillation is the key!).

Generate Test Solution

@time sol = solve(oprob, CVODE_BDF(), abstol=1/10^14, reltol=1/10^14)
test_sol  = TestSolution(sol)
0.218112 seconds (625.67 k allocations: 35.934 MiB, 90.59% compilation ti
me)
retcode: Success
Interpolation: 3rd order Hermite
t: nothing
u: nothing

Setups


abstols = 1.0 ./ 10.0 .^ (9:13)
reltols = 1.0 ./ 10.0 .^ (6:10)

setups = [
            Dict(:alg=>CVODE_BDF()),
            Dict(:alg=>KenCarp4()),
            Dict(:alg=>Rodas4()),
            Dict(:alg=>QNDF()),
            Dict(:alg=>lsoda()),
            Dict(:alg=>radau()),
            Dict(:alg=>seulex()),
            Dict(:alg=>ImplicitEulerExtrapolation(min_order = 8, init_order = 9,threading = OrdinaryDiffEq.PolyesterThreads())),
            Dict(:alg=>ImplicitEulerExtrapolation(min_order = 8, init_order = 9,threading = false)),
            Dict(:alg=>ImplicitEulerBarycentricExtrapolation(min_order = 7, init_order = 8,threading = OrdinaryDiffEq.PolyesterThreads())),
            Dict(:alg=>ImplicitEulerBarycentricExtrapolation(min_order = 7, init_order = 8,threading = false)),
            Dict(:alg=>ImplicitHairerWannerExtrapolation(init_order = 5,threading = OrdinaryDiffEq.PolyesterThreads())),
            Dict(:alg=>ImplicitHairerWannerExtrapolation(init_order = 5, threading = false)),
            ]

solnames = ["CVODE_BDF","KenCarp4","Rodas4","QNDF","lsoda","radau","seulex","ImplEulerExtpl (threaded)", "ImplEulerExtpl (non-threaded)",
            "ImplEulerBaryExtpl (threaded)","ImplEulerBaryExtpl (non-threaded)","ImplHWExtpl (threaded)","ImplHWExtpl (non-threaded)"]
13-element Vector{String}:
 "CVODE_BDF"
 "KenCarp4"
 "Rodas4"
 "QNDF"
 "lsoda"
 "radau"
 "seulex"
 "ImplEulerExtpl (threaded)"
 "ImplEulerExtpl (non-threaded)"
 "ImplEulerBaryExtpl (threaded)"
 "ImplEulerBaryExtpl (non-threaded)"
 "ImplHWExtpl (threaded)"
 "ImplHWExtpl (non-threaded)"

Automatic Jacobian Solves

First we test using auto-generated Jacobians (finite difference)

wp = WorkPrecisionSet(oprob,abstols,reltols,setups;
                      names = solnames,appxsol=test_sol,save_everystep=false,maxiters=Int(1e5),numruns=10)

plot(wp, title = "Implicit Methods: SBML Model",legend=:outertopleft,size = (1000,500),
     xticks = 10.0 .^ (-15:1:1),
     yticks = 10.0 .^ (-6:0.3:5),
     bottom_margin= 5Plots.mm)

Analytical Jacobian

Now we test using the generated analytic Jacobian function.

setups = [
            Dict(:alg=>CVODE_BDF()),
            Dict(:alg=>KenCarp4()),
            Dict(:alg=>Rodas4()),
            Dict(:alg=>QNDF()),
            #Dict(:alg=>lsoda()),
            #Dict(:alg=>radau()),
            #Dict(:alg=>seulex()),
            Dict(:alg=>ImplicitEulerExtrapolation(min_order = 8, init_order = 9,threading = OrdinaryDiffEq.PolyesterThreads())),
            Dict(:alg=>ImplicitEulerExtrapolation(min_order = 8, init_order = 9,threading = false)),
            Dict(:alg=>ImplicitEulerBarycentricExtrapolation(min_order = 7, init_order = 8,threading = OrdinaryDiffEq.PolyesterThreads())),
            Dict(:alg=>ImplicitEulerBarycentricExtrapolation(min_order = 7, init_order = 8,threading = false)),
            Dict(:alg=>ImplicitHairerWannerExtrapolation(init_order = 5,threading = OrdinaryDiffEq.PolyesterThreads())),
            Dict(:alg=>ImplicitHairerWannerExtrapolation(init_order = 5, threading = false)),
            ]

solnames = ["CVODE_BDF","KenCarp4","Rodas4","QNDF","ImplEulerExtpl (threaded)", "ImplEulerExtpl (non-threaded)",
            "ImplEulerBaryExtpl (threaded)","ImplEulerBaryExtpl (non-threaded)","ImplHWExtpl (threaded)","ImplHWExtpl (non-threaded)"]

wp = WorkPrecisionSet(densejacprob,abstols,reltols,setups;
                      names = solnames,appxsol=test_sol,save_everystep=false,maxiters=Int(1e5),numruns=10)

plot(wp, title = "Implicit Methods: SBML Model",legend=:outertopleft,size = (1000,500),
     xticks = 10.0 .^ (-15:1:1),
     yticks = 10.0 .^ (-6:0.3:5),
     bottom_margin= 5Plots.mm)

Sparse Jacobian

Finally we test using the generated sparse analytic Jacobian function.

Note that the extrapolation methods currently do not support sparse Jacobians.

setups = [
            #Dict(:alg=>CVODE_BDF()), #Fails!
            Dict(:alg=>KenCarp4(autodiff = false)),
            Dict(:alg=>Rodas4(autodiff = false)),
            Dict(:alg=>QNDF(autodiff = false)),
            #Dict(:alg=>lsoda()),
            #Dict(:alg=>radau()),
            #Dict(:alg=>seulex()),
            #Dict(:alg=>ImplicitEulerExtrapolation(autodiff = false,min_order = 8, init_order = 9,threading = OrdinaryDiffEq.PolyesterThreads())),
            #Dict(:alg=>ImplicitEulerExtrapolation(autodiff = false,min_order = 8, init_order = 9,threading = false)),
            #Dict(:alg=>ImplicitEulerBarycentricExtrapolation(autodiff = false,min_order = 7, init_order = 8,threading = OrdinaryDiffEq.PolyesterThreads())),
            #Dict(:alg=>ImplicitEulerBarycentricExtrapolation(autodiff = false,min_order = 7, init_order = 8,threading = false)),
            #Dict(:alg=>ImplicitHairerWannerExtrapolation(autodiff = false,init_order = 5,threading = OrdinaryDiffEq.PolyesterThreads())),
            #Dict(:alg=>ImplicitHairerWannerExtrapolation(autodiff = false,init_order = 5, threading = false)),
            ]

solnames = ["KenCarp4","Rodas4","QNDF",#"ImplEulerExtpl (threaded)", "ImplEulerExtpl (non-threaded)",
            #"ImplEulerBaryExtpl (threaded)","ImplEulerBaryExtpl (non-threaded)","ImplHWExtpl (threaded)","ImplHWExtpl (non-threaded)"
            ]

wp = WorkPrecisionSet(sparsejacprob ,abstols,reltols,setups;
                      names = solnames,appxsol=test_sol,save_everystep=false,maxiters=Int(1e5),numruns=10)

plot(wp, title = "Implicit Methods: SBML Model",legend=:outertopleft,size = (1000,500),
     xticks = 10.0 .^ (-15:1:1),
     yticks = 10.0 .^ (-6:0.3:5),
     bottom_margin= 5Plots.mm)

Appendix

These benchmarks are a part of the SciMLBenchmarks.jl repository, found at: https://github.com/SciML/SciMLBenchmarks.jl. For more information on high-performance scientific machine learning, check out the SciML Open Source Software Organization https://sciml.ai.

To locally run this benchmark, do the following commands:

using SciMLBenchmarks
SciMLBenchmarks.weave_file("benchmarks/Bio","Bidkhori2012.jmd")

Computer Information:

Julia Version 1.8.3
Commit 0434deb161e (2022-11-14 20:14 UTC)
Platform Info:
  OS: Linux (x86_64-linux-gnu)
  CPU: 128 × AMD EPYC 7502 32-Core Processor
  WORD_SIZE: 64
  LIBM: libopenlibm
  LLVM: libLLVM-13.0.1 (ORCJIT, znver2)
  Threads: 128 on 128 virtual cores
Environment:
  JULIA_CPU_THREADS = 128
  JULIA_DEPOT_PATH = /cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953
  LD_LIBRARY_PATH = /cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/7661e5a9aa217ce3c468389d834a4fb43b0911e8/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/2e8fae88dcadc37883e31246fe7397f4f1039f88/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/d00220164876dea2cb19993200662745eed5e2db/lib:/cache/julia-buildkite-plugin/julia_installs/bin/linux/x64/1.8/julia-1.8-latest-linux-x86_64/bin/../lib/julia:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/3e19866657986912870f596aecfee137473965a9/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/dc526f26fb179a3f68eb13fcbe5d2d2a5aa7eeac/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/5a508a62784097dab7c7ae5805f2c89d2cc97397/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/303fe895f57042ea41055187ec4af6322989b5cc/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/f3337de0321b3370b90643d18bf63bd4ee79c991/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/ddfc455343aff48d27c1b39d7fcb07e0d9242b50/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/54c97eb1b0a6f74bac96297a815ddec2204a7db7/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/2b77b304b0975d15bd5aeb4d1d5097ac6256ea3c/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/fac7e6d8fc4c5775bf5118ab494120d2a0db4d64/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/387d89822da323c098aba6f8ab316874d4e90f2e/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/16154f990153825ec24b52aac11165df2084b9dc/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/92111ef825c608ea220f8e679dd8d908d7ac5b83/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/f3ec73d7bf2f4419ba0943e94f7738cf56050797/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/4487a7356408c3a92924e56f9d3891724855282c/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/51c48c945ae76d6c0102649044d9976d93b78125/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/5ba11d7fb2ceb4ca812844eb4af886a212b47f65/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/431a0e3706ffe717ab5d35c47bc38626c6169504/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/fc6071b99b67da0ae4e49ebab70c369ce9a76c9e/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/527e66fb9b12dfd1f58157fe0b3fd52b84062432/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/921a059ebce52878d7a7944c9c345327958d1f5b/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/8b0284dc2781b9481ff92e281f1db532d8421040/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/d11639e2a53726f2593e25ba98ed7b416f62bbc5/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/62c010876222f83fe8878bf2af0e362083d20ee3/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/ee20a84d0166c074dfa736b642902dd87b4da48d/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/459252c01ffcd08700841efdd4b6d3edfe5916e7/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/cc415631aeb190b075329ce756f690a90e1f873b/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/e19f3bb2eef5fb956b672235ea5323b5be9a0626/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/0631e2a6a31b5692eec7a575836451b16b734ec0/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/89ed5dda220da4354ada1970107e13679914bbbc/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/595f9476b128877ab5bf73883ff6c8dc8dacfe66/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/587de110e5f58fd435dc35b294df31bb7a75f692/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/fc239b3ff5739aeab252bd154fa4dd045fefe629/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/25fa81dbac6496585a91dbdc258273d39442466f/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/eff86eedadb59cff1a61399e3242b3f529ca6f59/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/b409c0eafb4254a980f9e730f6fbe56867890f6a/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/a84cc58d5161b950f268bb562e105bbbf4d6004a/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/f0d193662fead3500b523f94b4f1878daab59a93/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/05616da88f6b36c7c94164d4070776aef18ce46b/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/2df316da869cd97f7d70029428ee1e2e521407cd/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/7190f0cb0832b80761cc6d513dd9b935f3e26358/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/4daa3879a820580557ef34945e2ae243dfcbba11/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/5aa80c7b8e919cbfee41019069d9b25269befe10/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/8793267ae1f4b96f626caa27147aa0218389c30d/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/694cae97bb3cbf8f1f73f2ecabd891602ccf1751/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/d22cde7583df1d5f71160a8e4676955a66a91f33/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/b610fc4e040c9a46c250ea4792cc64098003578a/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/cacd8c147f866d6672e1aca9bb01fb919a81e96a/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/b7dc5dce963737414a564aca8d4b82ee388f4fa1/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/0d364e900393f710a03a5bafe2852d76e4d2c2cd/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/79cc5446ced978de84b6e673e01da0ebfdd6e4a5/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/1a2adcee7d99fea18ead33c350332626b262e29a/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/84f18b0f422f5d6a023fe871b59a9fc536d04f5c/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/3c7eef5f322b19cd4b5db6b21f8cafda87b8b26c/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/4443e44120d70a97f8094a67268a886256077e69/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/988066cc974e30c89774b0c471f47201975a4423/lib:/cache/julia-buildkite-plugin/depots/5b300254-1738-4989-ae0a-f4d2d937f953/artifacts/26099abd23e11fc440259049997307380be745c8/lib:/cache/julia-buildkite-plugin/julia_installs/bin/linux/x64/1.8/julia-1.8-latest-linux-x86_64/bin/../lib/julia:/cache/julia-buildkite-plugin/julia_installs/bin/linux/x64/1.8/julia-1.8-latest-linux-x86_64/bin/../lib:

Package Information:

Status `/cache/build/exclusive-amdci1-0/julialang/scimlbenchmarks-dot-jl/benchmarks/Bio/Project.toml`
⌃ [6e4b80f9] BenchmarkTools v1.3.1
⌃ [479239e8] Catalyst v12.3.0
⌃ [2b5f629d] DiffEqBase v6.105.0
⌃ [f3b72e0c] DiffEqDevTools v2.32.0
⌃ [40713840] IncompleteLU v0.2.0
⌃ [033835bb] JLD2 v0.4.24
⌃ [7f56f5a3] LSODA v0.7.0
⌃ [7ed4a6bd] LinearSolve v1.26.0
⌃ [961ee093] ModelingToolkit v8.26.1
  [54ca160b] ODEInterface v0.5.0
  [09606e27] ODEInterfaceDiffEq v3.11.0
⌃ [1dea7af3] OrdinaryDiffEq v6.28.0
⌃ [91a5bcdd] Plots v1.35.2
⌃ [b4db0fb7] ReactionNetworkImporters v0.13.4
  [31c91b34] SciMLBenchmarks v0.1.1
⌃ [c3572dad] Sundials v4.10.1
⌃ [a759f4b9] TimerOutputs v0.5.21
Info Packages marked with ⌃ have new versions available and may be upgradable.
Warning The project dependencies or compat requirements have changed since the manifest was last resolved. It is recommended to `Pkg.resolve()` or consider `Pkg.update()` if necessary.

And the full manifest:

Status `/cache/build/exclusive-amdci1-0/julialang/scimlbenchmarks-dot-jl/benchmarks/Bio/Manifest.toml`
⌃ [c3fe647b] AbstractAlgebra v0.27.4
⌃ [1520ce14] AbstractTrees v0.4.2
  [79e6a3ab] Adapt v3.4.0
  [dce04be8] ArgCheck v2.3.0
  [ec485272] ArnoldiMethod v0.2.0
⌃ [4fba245c] ArrayInterface v6.0.23
⌃ [30b0a656] ArrayInterfaceCore v0.1.20
  [6ba088a2] ArrayInterfaceGPUArrays v0.2.2
⌃ [015c0d05] ArrayInterfaceOffsetArrays v0.1.6
⌃ [b0d46f97] ArrayInterfaceStaticArrays v0.1.4
⌃ [dd5226c6] ArrayInterfaceStaticArraysCore v0.1.0
  [15f4f7f2] AutoHashEquals v0.2.0
  [198e06fe] BangBang v0.3.37
  [9718e550] Baselet v0.1.1
⌃ [6e4b80f9] BenchmarkTools v1.3.1
  [e2ed5e7c] Bijections v0.1.4
  [9e28174c] BinDeps v1.0.2
⌃ [d1d4a3ce] BitFlags v0.1.5
⌃ [62783981] BitTwiddlingConvenienceFunctions v0.1.4
  [fa961155] CEnum v0.4.2
⌃ [2a0fbf3d] CPUSummary v0.1.27
  [00ebfdb7] CSTParser v3.3.6
  [49dc2e85] Calculus v0.5.1
⌃ [479239e8] Catalyst v12.3.0
  [d360d2e6] ChainRulesCore v1.15.6
  [9e997f8a] ChangesOfVariables v0.1.4
⌃ [fb6a15b2] CloseOpenIntervals v0.1.10
  [944b1d66] CodecZlib v0.7.0
  [35d6a980] ColorSchemes v3.19.0
  [3da002f7] ColorTypes v0.11.4
  [c3611d14] ColorVectorSpace v0.9.9
  [5ae59095] Colors v0.12.8
  [861a8166] Combinatorics v1.0.2
⌃ [a80b9123] CommonMark v0.8.6
⌃ [38540f10] CommonSolve v0.2.1
  [bbf7d656] CommonSubexpressions v0.3.0
⌅ [34da2185] Compat v3.46.0
⌃ [b152e2b5] CompositeTypes v0.1.2
  [a33af91c] CompositionsBase v0.1.1
  [8f4d0f93] Conda v1.7.0
  [187b0558] ConstructionBase v1.4.1
  [d38c429a] Contour v0.6.2
  [adafc99b] CpuId v0.3.1
  [a8cc5b0e] Crayons v4.1.1
⌃ [9a962f9c] DataAPI v1.12.0
  [864edb3b] DataStructures v0.18.13
  [e2d170a0] DataValueInterfaces v1.0.0
  [244e2a9f] DefineSingletons v0.1.2
  [b429d917] DensityInterface v0.4.0
⌃ [2b5f629d] DiffEqBase v6.105.0
⌃ [459566f4] DiffEqCallbacks v2.24.1
⌃ [f3b72e0c] DiffEqDevTools v2.32.0
⌃ [77a26b50] DiffEqNoiseProcess v5.13.0
  [163ba53b] DiffResults v1.1.0
⌃ [b552c78f] DiffRules v1.11.1
  [b4f34e82] Distances v0.10.7
⌃ [31c24e10] Distributions v0.25.75
⌅ [ffbed154] DocStringExtensions v0.8.6
⌃ [5b8099bc] DomainSets v0.5.13
  [fa6b7ba4] DualNumbers v0.6.8
  [7c1d4256] DynamicPolynomials v0.4.5
⌃ [d4d017d3] ExponentialUtilities v1.19.0
  [e2ba6199] ExprTools v0.1.8
  [c87230d0] FFMPEG v0.4.1
⌃ [7034ab61] FastBroadcast v0.2.1
  [9aa1b823] FastClosures v0.3.2
  [29a986be] FastLapackInterface v1.2.7
⌃ [5789e2e9] FileIO v1.15.0
⌃ [1a297f60] FillArrays v0.13.4
⌃ [6a86dc24] FiniteDiff v2.15.0
  [53c48c17] FixedPointNumbers v0.8.4
  [59287772] Formatting v0.4.2
⌃ [f6369f11] ForwardDiff v0.10.32
  [069b7b12] FunctionWrappers v1.1.3
  [77dc65aa] FunctionWrappersWrappers v0.1.1
  [46192b85] GPUArraysCore v0.1.2
⌅ [28b8d3ca] GR v0.69.3
  [c145ed77] GenericSchur v0.5.3
  [d7ba0133] Git v1.2.1
  [86223c79] Graphs v1.7.4
  [42e2da0e] Grisu v1.0.2
⌃ [0b43b601] Groebner v0.2.10
  [d5909c97] GroupsCore v0.4.0
⌃ [cd3eb016] HTTP v1.4.0
⌅ [eafb193a] Highlights v0.4.5
⌃ [3e5b6fbb] HostCPUFeatures v0.1.8
  [34004b35] HypergeometricFunctions v0.3.11
  [7073ff75] IJulia v1.23.3
  [615f187c] IfElse v0.1.1
⌃ [40713840] IncompleteLU v0.2.0
  [d25df0c9] Inflate v0.1.3
  [83e8ac13] IniFile v0.5.1
  [22cec73e] InitialValues v0.3.1
  [18e54dd8] IntegerMathUtils v0.1.0
  [8197267c] IntervalSets v0.7.3
  [3587e190] InverseFunctions v0.1.8
  [92d709cd] IrrationalConstants v0.1.1
  [42fd0dbc] IterativeSolvers v0.9.2
  [82899510] IteratorInterfaceExtensions v1.0.0
⌃ [033835bb] JLD2 v0.4.24
  [1019f520] JLFzf v0.1.5
  [692b3bcd] JLLWrappers v1.4.1
  [682c06a0] JSON v0.21.3
⌃ [98e50ef6] JuliaFormatter v1.0.10
⌃ [ccbc3e58] JumpProcesses v9.2.0
⌅ [ef3ab10e] KLU v0.3.0
  [ba0b0d4f] Krylov v0.8.4
⌅ [0b1a1467] KrylovKit v0.5.4
⌃ [7f56f5a3] LSODA v0.7.0
  [b964fa9f] LaTeXStrings v1.3.0
⌃ [2ee39098] LabelledArrays v1.12.0
  [23fbe1c1] Latexify v0.15.17
⌃ [10f19ff3] LayoutPointers v0.1.10
  [d3d80556] LineSearches v7.2.0
⌃ [7ed4a6bd] LinearSolve v1.26.0
⌃ [2ab3a3ac] LogExpFunctions v0.3.18
⌅ [e6f89c97] LoggingExtras v0.4.9
⌃ [bdcacae8] LoopVectorization v0.12.132
  [1914dd2f] MacroTools v0.5.10
  [d125e4d3] ManualMemory v0.1.8
⌃ [739be429] MbedTLS v1.1.6
⌃ [442fdcdd] Measures v0.3.1
  [e9d8d322] Metatheory v1.3.5
⌃ [128add7d] MicroCollections v0.1.2
  [e1d29d7a] Missings v1.0.2
⌃ [961ee093] ModelingToolkit v8.26.1
⌃ [46d2c3a1] MuladdMacro v0.2.2
  [102ac46a] MultivariatePolynomials v0.4.6
  [ffc61752] Mustache v1.0.14
⌃ [d8a4904e] MutableArithmetics v1.0.4
⌃ [d41bc354] NLSolversBase v7.8.2
  [2774e3e8] NLsolve v4.5.1
  [77ba4419] NaNMath v1.0.1
  [8913a72c] NonlinearSolve v0.3.22
  [54ca160b] ODEInterface v0.5.0
  [09606e27] ODEInterfaceDiffEq v3.11.0
⌃ [6fe1bfb0] OffsetArrays v1.12.7
⌃ [4d8831e6] OpenSSL v1.2.1
⌃ [429524aa] Optim v1.7.3
  [bac558e1] OrderedCollections v1.4.1
⌃ [1dea7af3] OrdinaryDiffEq v6.28.0
  [90014a1f] PDMats v0.11.16
  [d96e819e] Parameters v0.12.3
⌃ [69de0a69] Parsers v2.4.0
  [b98c9c47] Pipe v1.3.0
⌃ [ccf2f8ad] PlotThemes v3.0.0
  [995b91a9] PlotUtils v1.3.1
⌃ [91a5bcdd] Plots v1.35.2
⌃ [e409e4f3] PoissonRandom v0.4.1
⌃ [f517fe37] Polyester v0.6.15
⌃ [1d0040c9] PolyesterWeave v0.1.10
  [85a6dd25] PositiveFactorizations v0.2.4
  [d236fae5] PreallocationTools v0.4.4
  [21216c6a] Preferences v1.3.0
  [27ebfcd6] Primes v0.5.3
⌃ [1fd47b50] QuadGK v2.5.0
  [74087812] Random123 v1.6.0
  [fb686558] RandomExtensions v0.4.3
  [e6cf234a] RandomNumbers v1.5.3
⌃ [b4db0fb7] ReactionNetworkImporters v0.13.4
⌃ [3cdcf5f2] RecipesBase v1.3.0
⌃ [01d81517] RecipesPipeline v0.6.6
⌃ [731186ca] RecursiveArrayTools v2.32.0
  [f2c3362d] RecursiveFactorization v0.2.12
  [189a3867] Reexport v1.2.2
  [42d2dcc6] Referenceables v0.1.2
  [05181044] RelocatableFolders v1.0.0
  [ae029012] Requires v1.3.0
  [ae5879a3] ResettableStacks v1.1.1
  [79098fc4] Rmath v0.7.0
⌃ [47965b36] RootedTrees v2.15.0
⌃ [7e49a35a] RuntimeGeneratedFunctions v0.5.3
  [3cdde19b] SIMDDualNumbers v0.1.1
  [94e857df] SIMDTypes v0.1.0
⌃ [476501e8] SLEEFPirates v0.6.36
⌃ [0bca4576] SciMLBase v1.59.4
  [31c91b34] SciMLBenchmarks v0.1.1
  [6c6a2e73] Scratch v1.1.1
⌅ [efcf1570] Setfield v0.8.2
  [992d4aef] Showoff v1.0.3
  [777ac1f9] SimpleBufferStream v1.1.0
  [699a6c99] SimpleTraits v0.9.4
  [47aef6b3] SimpleWeightedGraphs v1.2.1
  [66db9d55] SnoopPrecompile v1.0.1
  [b85f4697] SoftGlobalScope v1.1.0
⌃ [a2af1166] SortingAlgorithms v1.0.1
⌃ [47a9eef4] SparseDiffTools v1.26.2
  [276daf66] SpecialFunctions v2.1.7
⌃ [171d559e] SplittablesBase v0.1.14
⌅ [aedffcd0] Static v0.7.7
⌃ [90137ffa] StaticArrays v1.5.9
  [1e83bf80] StaticArraysCore v1.4.0
  [82ae8749] StatsAPI v1.5.0
  [2913bbd2] StatsBase v0.33.21
  [4c63d2b9] StatsFuns v1.0.1
⌅ [7792a7ef] StrideArraysCore v0.3.15
  [69024149] StringEncodings v0.3.5
⌃ [c3572dad] Sundials v4.10.1
  [d1185830] SymbolicUtils v0.19.11
⌃ [0c5d862f] Symbolics v4.10.4
  [3783bdb8] TableTraits v1.0.1
⌃ [bd369af6] Tables v1.9.0
  [62fd8b95] TensorCore v0.1.1
⌅ [8ea1fca8] TermInterface v0.2.3
  [8290d209] ThreadingUtilities v0.5.0
⌃ [ac1d9e8a] ThreadsX v0.1.10
⌃ [a759f4b9] TimerOutputs v0.5.21
  [0796e94c] Tokenize v0.5.24
  [3bb67fe8] TranscodingStreams v0.9.9
  [28d57a85] Transducers v0.4.74
  [a2a6695c] TreeViews v0.3.0
⌃ [d5829a12] TriangularSolve v0.1.14
  [410a4b4d] Tricks v0.1.6
  [30578b45] URIParser v0.4.1
  [5c2747f8] URIs v1.4.0
  [3a884ed6] UnPack v1.0.2
  [1cfade01] UnicodeFun v0.4.1
⌃ [1986cc42] Unitful v1.12.0
  [41fe7b60] Unzip v0.2.0
⌃ [3d5dd08c] VectorizationBase v0.21.51
  [81def892] VersionParsing v1.3.0
  [19fa3120] VertexSafeGraphs v0.2.0
⌃ [44d3d7a6] Weave v0.10.9
⌃ [ddb6d928] YAML v0.4.7
⌃ [c2297ded] ZMQ v1.2.1
  [700de1a5] ZygoteRules v0.2.2
  [6e34b625] Bzip2_jll v1.0.8+0
  [83423d85] Cairo_jll v1.16.1+1
  [2e619515] Expat_jll v2.4.8+0
  [b22a6f82] FFMPEG_jll v4.4.2+2
  [a3f928ae] Fontconfig_jll v2.13.93+0
  [d7e528f0] FreeType2_jll v2.10.4+0
  [559328eb] FriBidi_jll v1.0.10+0
  [0656b61e] GLFW_jll v3.3.8+0
⌅ [d2c73de3] GR_jll v0.69.1+0
  [78b55507] Gettext_jll v0.21.0+0
  [f8c6e375] Git_jll v2.34.1+0
  [7746bdde] Glib_jll v2.74.0+1
  [3b182d85] Graphite2_jll v1.3.14+0
  [2e76f6c2] HarfBuzz_jll v2.8.1+1
  [aacddb02] JpegTurbo_jll v2.1.2+0
  [c1c5ebd0] LAME_jll v3.100.1+0
  [88015f11] LERC_jll v3.0.0+1
  [aae0fff6] LSODA_jll v0.1.1+0
  [dd4b983a] LZO_jll v2.10.1+0
⌅ [e9f186c6] Libffi_jll v3.2.2+1
  [d4300ac3] Libgcrypt_jll v1.8.7+0
  [7e76a0d4] Libglvnd_jll v1.3.0+3
  [7add5ba3] Libgpg_error_jll v1.42.0+0
  [94ce4f54] Libiconv_jll v1.16.1+1
  [4b2f31a3] Libmount_jll v2.35.0+0
  [89763e89] Libtiff_jll v4.4.0+0
  [38a345b3] Libuuid_jll v2.36.0+0
  [c771fb93] ODEInterface_jll v0.0.1+0
  [e7412a2a] Ogg_jll v1.3.5+1
⌃ [458c3c95] OpenSSL_jll v1.1.17+0
  [efe28fd5] OpenSpecFun_jll v0.5.5+0
  [91d4177d] Opus_jll v1.3.2+0
  [30392449] Pixman_jll v0.40.1+0
⌃ [ea2cea3b] Qt5Base_jll v5.15.3+1
  [f50d1b31] Rmath_jll v0.3.0+0
  [fb77eaff] Sundials_jll v5.2.1+0
  [a2964d1f] Wayland_jll v1.19.0+0
  [2381bf8a] Wayland_protocols_jll v1.25.0+0
  [02c8fc9c] XML2_jll v2.9.14+0
  [aed1982a] XSLT_jll v1.1.34+0
  [4f6342f7] Xorg_libX11_jll v1.6.9+4
  [0c0b7dd1] Xorg_libXau_jll v1.0.9+4
  [935fb764] Xorg_libXcursor_jll v1.2.0+4
  [a3789734] Xorg_libXdmcp_jll v1.1.3+4
  [1082639a] Xorg_libXext_jll v1.3.4+4
  [d091e8ba] Xorg_libXfixes_jll v5.0.3+4
  [a51aa0fd] Xorg_libXi_jll v1.7.10+4
  [d1454406] Xorg_libXinerama_jll v1.1.4+4
  [ec84b674] Xorg_libXrandr_jll v1.5.2+4
  [ea2f1a96] Xorg_libXrender_jll v0.9.10+4
  [14d82f49] Xorg_libpthread_stubs_jll v0.1.0+3
  [c7cfdc94] Xorg_libxcb_jll v1.13.0+3
  [cc61e674] Xorg_libxkbfile_jll v1.1.0+4
  [12413925] Xorg_xcb_util_image_jll v0.4.0+1
  [2def613f] Xorg_xcb_util_jll v0.4.0+1
  [975044d2] Xorg_xcb_util_keysyms_jll v0.4.0+1
  [0d47668e] Xorg_xcb_util_renderutil_jll v0.3.9+1
  [c22f9ab0] Xorg_xcb_util_wm_jll v0.4.1+1
  [35661453] Xorg_xkbcomp_jll v1.4.2+4
  [33bec58e] Xorg_xkeyboard_config_jll v2.27.0+4
  [c5fb5394] Xorg_xtrans_jll v1.4.0+3
  [8f1865be] ZeroMQ_jll v4.3.4+0
  [3161d3a3] Zstd_jll v1.5.2+0
⌅ [214eeab7] fzf_jll v0.29.0+0
  [a4ae2306] libaom_jll v3.4.0+0
  [0ac62f75] libass_jll v0.15.1+0
  [f638f0a6] libfdk_aac_jll v2.0.2+0
  [b53b4c65] libpng_jll v1.6.38+0
  [a9144af2] libsodium_jll v1.0.20+0
  [f27f6e37] libvorbis_jll v1.3.7+1
  [1270edf5] x264_jll v2021.5.5+0
  [dfaa095f] x265_jll v3.5.0+0
  [d8fb68d0] xkbcommon_jll v1.4.1+0
  [0dad84c5] ArgTools v1.1.1
  [56f22d72] Artifacts
  [2a0f44e3] Base64
  [ade2ca70] Dates
  [8bb1440f] DelimitedFiles
  [8ba89e20] Distributed
  [f43a241f] Downloads v1.6.0
  [7b1f6079] FileWatching
  [9fa8497b] Future
  [b77e0a4c] InteractiveUtils
  [b27032c2] LibCURL v0.6.3
  [76f85450] LibGit2
  [8f399da3] Libdl
  [37e2e46d] LinearAlgebra
  [56ddb016] Logging
  [d6f4376e] Markdown
  [a63ad114] Mmap
  [ca575930] NetworkOptions v1.2.0
  [44cfe95a] Pkg v1.8.0
  [de0858da] Printf
  [9abbd945] Profile
  [3fa0cd96] REPL
  [9a3f8284] Random
  [ea8e919c] SHA v0.7.0
  [9e88b42a] Serialization
  [1a1011a3] SharedArrays
  [6462fe0b] Sockets
  [2f01184e] SparseArrays
  [10745b16] Statistics
  [4607b0f0] SuiteSparse
  [fa267f1f] TOML v1.0.0
  [a4e569a6] Tar v1.10.1
  [8dfed614] Test
  [cf7118a7] UUIDs
  [4ec0a83e] Unicode
  [e66e0078] CompilerSupportLibraries_jll v0.5.2+0
  [deac9b47] LibCURL_jll v7.84.0+0
  [29816b5a] LibSSH2_jll v1.10.2+0
  [c8ffd9c3] MbedTLS_jll v2.28.0+0
  [14a3606d] MozillaCACerts_jll v2022.2.1
  [4536629a] OpenBLAS_jll v0.3.20+0
  [05823500] OpenLibm_jll v0.8.1+0
  [efcefdf7] PCRE2_jll v10.40.0+0
  [bea87d4a] SuiteSparse_jll v5.10.1+0
  [83775a58] Zlib_jll v1.2.12+3
  [8e850b90] libblastrampoline_jll v5.1.1+0
  [8e850ede] nghttp2_jll v1.48.0+0
  [3f19e933] p7zip_jll v17.4.0+0
Info Packages marked with ⌃ and ⌅ have new versions available, but those with ⌅ are restricted by compatibility constraints from upgrading. To see why use `status --outdated -m`
Warning The project dependencies or compat requirements have changed since the manifest was last resolved. It is recommended to `Pkg.resolve()` or consider `Pkg.update()` if necessary.